Skeletal Radiology

, Volume 33, Issue 9, pp 524–530 | Cite as

Carbon-11-methionine positron emission tomography imaging of chordoma

  • Hong Zhang
  • Kyosan YoshikawaEmail author
  • Katsumi Tamura
  • Kenji Sagou
  • Mei Tian
  • Tetsuya Suhara
  • Susumu Kandatsu
  • Kazutoshi Suzuki
  • Shuji Tanada
  • Hirohiko Tsujii



Chordoma is a rare malignant bone tumor that arises from notochord remnants. This is the first trial to investigate the utility of 11C-methionine (MET) positron emission tomography (PET) in the imaging of chordoma before and after carbon-ion radiotherapy (CIRT).

Design and patients

Fifteen patients with chordoma were investigated with MET-PET before and after CIRT and the findings analyzed visually and quantitatively. Tumor MET uptake was evaluated by tumor-to-nontumor ratio (T/N ratio).


In 12 (80%) patients chordoma was clearly visible in the baseline MET-PET study with a mean T/N ratio of 3.3±1.7. The MET uptake decreased significantly to 2.3±1.4 after CIRT (P<0.05). A significant reduction in tumor MET uptake of 24% was observed after CIRT. Fourteen (93%) patients showed no local recurrence after CIRT with a median follow-up time of 20 months.


This study has demonstrated that MET-PET is feasible for imaging of chordoma. MET-PET could provide important tumor metabolic information for the therapeutic monitoring of chordoma after CIRT.


Chordoma 11C-methionine PET Carbon ion radiotherapy Diagnosis 


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Copyright information

© ISS 2004

Authors and Affiliations

  • Hong Zhang
    • 1
    • 2
  • Kyosan Yoshikawa
    • 3
    Email author
  • Katsumi Tamura
    • 3
  • Kenji Sagou
    • 3
  • Mei Tian
    • 1
  • Tetsuya Suhara
    • 1
  • Susumu Kandatsu
    • 3
  • Kazutoshi Suzuki
    • 1
  • Shuji Tanada
    • 1
  • Hirohiko Tsujii
    • 4
  1. 1.Department of Medical ImagingNational Institute of Radiological SciencesChibaJapan
  2. 2.Department of Medical Imaging, Research Center Hospital for Charged Particle TherapyNational Institute of Radiological SciencesChibaJapan
  3. 3.Clinical Diagnosis SectionNational Institute of Radiological SciencesChibaJapan
  4. 4.Research Center for Charged Particle TherapyNational Institute of Radiological SciencesChibaJapan

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