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Malignant giant cell tumor of soft parts

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Abstract

Giant cell tumor of soft parts (GCTSP) is an extremely rare lesion with an unpredictable behavior. Some patients are cured with a simple surgical excision whereas others will develop metastatic disease within a relatively short interval. To date, there are no consistently reliable criteria, either clinical or histologic, to separate the benign from more aggressive lesions. We describe the clinical, histologic and radiologic features of a case with malignant behavior. The patient presented with a fungating skin and soft tissue mass and concurrent pulmonary nodules. The lesion recurred rapidly despite wide resection with negative surgical margins. Biopsy of the pulmonary lesions demonstrated metastatic disease.

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References

  1. Salm R, Sissons HA. Giant-cell tumors of soft tissues. J Pathol 1972; 107:27–39.

    CAS  PubMed  Google Scholar 

  2. Oliveira AM, Dei Tos, AP, Fletcher CDM, Nascimento AG. Primary giant cell tumor of soft tissues: a study of 22 cases. Am J Surg Pathol 2000; 24:248–256.

    CAS  PubMed  Google Scholar 

  3. Alguacil-Garcia A, Unni KK, Goellner JR. Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. Cancer 1977; 40:244–53.

    CAS  PubMed  Google Scholar 

  4. Angervall L, Hagmar B, Kindblom LG, Merck C. Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic and microangiographic study. Cancer 1981; 47:736–747.

    CAS  PubMed  Google Scholar 

  5. Guccion JG, Enzinger FM. Malignant giant cell tumor of soft parts. An analysis of 32 cases. Cancer 1972; 29:1518–1529.

    CAS  PubMed  Google Scholar 

  6. Robins RE, Johnstone FRC, Worth A, Fris RJ. The importance of recognizing malignant giant cell tumor of soft parts. Am J Surg 1978; 136:102–106.

    CAS  PubMed  Google Scholar 

  7. Folpe AL, Morrise RJ, Weiss SW. Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. Mod Pathol 1999; 12:894–902.

    CAS  PubMed  Google Scholar 

  8. Gould E, Albores-Saavedra J, Rothe M, Mnaymneh W, Menendez-Aponte S. Malignant giant cell tumor of soft parts presenting as a skin tumor. Am J Dermopathol 1989; 11:197–201.

    CAS  Google Scholar 

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Correspondence to Leslie G. Dodd.

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Dodd, L.G., Major, N. & Brigman, B. Malignant giant cell tumor of soft parts. Skeletal Radiol 33, 295–299 (2004). https://doi.org/10.1007/s00256-003-0744-8

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  • DOI: https://doi.org/10.1007/s00256-003-0744-8

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