Abstract
Clear cell sarcoma is a rare soft tissue sarcoma of young adults with melanocytic differentiation. It occurs predominantly in the soft tissue of extremities, typically involving tendons and aponeuroses. Primary clear cell sarcoma of bone is extremely rare. We report a case of primary clear cell sarcoma of the right first metatarsal in a 48-year-old woman and provide a literature review of the entity.
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Enzinger FM. Clear cell sarcoma of tendons and aponeuroses: an analysis of 21 cases. Cancer 1965; 18:1163–1174.
Sciot R, Speleman F. Clear cell sarcoma of soft tissue. In: Fletcher CDM, Unni KK, Mertens F, eds. World Health Organization Classification of Tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press, 2002: 211–212.
Ekfors TO, Kujari H, Isomaki M. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) in the duodenum: the first visceral case. Histopathology 1993; 22:255–259.
Donner LR, Trompler EA, Dobin S. Clear cell sarcoma of the ileum: the crucial role of cytogenetics for the diagnosis. Am J Surg Pathol 1998; 22:121–124.
Fukuda T, Kakihara T, Baba K, Yamaki T, Yamaguchi T, Suzuki T. Clear cell sarcoma arsining in the transverse colon. Pathol Int 2000; 50:412–416.
Saw D, Tse CH, Chan J, Watt CY, Ng CS, Poon YF. Clear cell sarcoma of the penis. Hum Pathol 1986; 17:423–425.
Rubin BO, Fletcher JA, Renshaw AA. Clear cell sarcoma of soft parts: report of a case primary in the kidney with cytogenetic confirmation. Am J Surg Pathol 1999; 23:589–594.
Yokoyama R, Mukai K, Hirota T, Beppu Y, Fukuma H. Primary malignant melanoma (clear cell sarcoma) of bone. Report of a case arising in the ulna. Cancer 1996; 77:2471–2475.
Brekke MK, Northcote K, Temple WE. Clear cell sarcoma in the first metatarsal. An unusual case. J Am Podiatr Med Assoc 1998; 88:457–61.
Gelczer RK, Wenger DE, Wold LE. Primary clear cell sarcoma of bone: a unique site of origin. Skeletal Radiol 1999; 28:240–243.
Chung EB, Enzinger FM. Malignant melanoma of soft parts. A reassessment of clear cell sarcoma. Am J Surg Pathol 1983; 7:405–413.
Kempson RL, Fletcher CDM, Evans HL, Hendrickson MR, Silbley RK. Atlas of tumor pathology: tumors of the soft tissues. Third series. Fascicle 30, Washington, DC: Armed Forces Institute of Pathology, 2001: 464–466.
Miettinen M. Diagnostic soft tissue pathology. New York: Churchill Livingstone, 2003: 383–385.
Mrozek K, Karakousis CP, Perez-Mesa C, Bloomfield CD. Translocation t(12;22)(q13;q12.2–12.3) in a clear cell sarcoma of tendons and aponeuroses. Genes Chromosomes Cancer 1993; 6:249–252.
Sandberg AA, Bridge JA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumours: clear cell sarcoma (malignant melanoma of soft parts). Cancer Genetics Cytogenet 2001; 130:1–7.
Morishita S, Onomura T, Yamamoto S, Nakashima Y. Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) with unusual reontgenologic findings. Case report. Clin Orthop 1987; 216:276–279.
Lucas DR, Nascimento AG, Sim FH. Clear cell sarcoma of soft tissues. Mayo Clinic experience with 35 cases. Am J Surg Pathol 1992; 16:1197–1204.
Acknowledgements
The authors thank Unni, KK, M.D. (Department of Pathology, Mayo Clinic, MN), Swee, RG, M.D. and Wenger, DE, M.D. (Department of Radiology, Mayo Clinic, MN) for reviewing this case.
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Choi, J.H., Gu, M.J., Kim, M.J. et al. Primary clear cell sarcoma of bone. Skeletal Radiol 32, 598–602 (2003). https://doi.org/10.1007/s00256-003-0683-4
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DOI: https://doi.org/10.1007/s00256-003-0683-4