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Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus

Applied Microbiology and Biotechnology volume 104, pages 475–488 (2020)Cite this article

Abstract

Among the so-called non-conventional yeasts, Kluyveromyces marxianus has extremely potent traits that are suitable for industrial applications. Indeed, it has been used for the production of various enzymes, chemicals, and macromolecules in addition to utilization of cell biomass as nutritional materials, feed and probiotics. The yeast is expected to be an efficient ethanol producer with advantages over Saccharomyces cerevisiae in terms of high growth rate, thermotolerance and a wide sugar assimilation spectrum. Results of comprehensive analyses of its genome and transcriptome may accelerate studies for applications of the yeast and may further increase its potential by combination with recent biotechnological tools including the CRISPR/Cas9 system. We thus review published studies by merging with information obtained from comprehensive data including genomic and transcriptomic data, which would be useful for future applications of K. marxianus.

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Affiliations

  1. Graduate School of Medicine, Yamaguchi University, Ube, 755-8505, Japan

    Mochamad Nurcholis & Mamoru Yamada

  2. Department of Food Science and Technology, Faculty of Agricultural Technology, Brawijaya University, Malang, 65145, Indonesia

    Mochamad Nurcholis

  3. Department of Microbiology, Faculty of Science, Kasetsart University, Bangkok, 10900, Thailand

    Noppon Lertwattanasakul

  4. Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nadchanok Rodrussamee

  5. Center of Excellence in Bioresources for Agriculture, Industry and Medicine, Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand

    Nadchanok Rodrussamee

  6. Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, 753-8515, Japan

    Tomoyuki Kosaka, Masayuki Murata & Mamoru Yamada

  7. Graduate School of Science and Technology for Innovation, Yamaguchi University, Yamaguchi, 753-8515, Japan

    Tomoyuki Kosaka, Masayuki Murata & Mamoru Yamada

  8. Research Center for Thermotolerant Microbial Resources, Yamaguchi University, Yamaguchi, 753-8515, Japan

    Tomoyuki Kosaka & Mamoru Yamada

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  1. Mochamad Nurcholis
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Nurcholis, M., Lertwattanasakul, N., Rodrussamee, N. et al. Integration of comprehensive data and biotechnological tools for industrial applications of Kluyveromyces marxianus. Appl Microbiol Biotechnol 104, 475–488 (2020). https://doi.org/10.1007/s00253-019-10224-3

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  • DOI: https://doi.org/10.1007/s00253-019-10224-3

Keywords

  • Kluyveromyces marxianus
  • Useful materials production
  • Transcriptome
  • Biotechnological tools
  • Glucose sensing
  • Mig1 regulation