A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137

Zhang, Jingyu; Li, Bixiao; Qin, Yujie; Karthik, Loganathan; Zhu, Guoliang; Hou, Chengjian; Jiang, Lan; Liu, Miaomiao; Ye, Xin; Liu, Mei; Hsiang, Tom; Dai, Huanqin; Zhang, Lixin; Liu, Xueting

doi:10.1007/s00253-019-10217-2

Biotechnological products and process engineering
Published: 02 January 2020

A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137

Jingyu Zhang¹^na1,
Bixiao Li^1,2,3^na1,
Yujie Qin³,
Loganathan Karthik^1,4,
Guoliang Zhu¹,
Chengjian Hou¹,
Lan Jiang¹,
Miaomiao Liu⁵,
Xin Ye³,
Mei Liu³,
Tom Hsiang⁶,
Huanqin Dai³,
Lixin Zhang ORCID: orcid.org/0000-0001-6581-6818¹ &
Xueting Liu¹

Applied Microbiology and Biotechnology volume 104, pages 1533–1543 (2020)Cite this article

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Abstract

Marine microorganisms live in dramatically different environments and have attracted much attention for their structurally unique natural products with potential strong biological activity. Based on the one strain-many compounds (OSMAC) strategy and liquid chromatography mass spectrometry (LC-MS) methods, our continuing efforts on the investigation of novel active compounds from marine Verrucosispora sp. MS100137 has led to the identification of a new polycyclic metabolite, abyssomicin Y (1), together with six known abyssomicin and proximicin analogs (2–7). Abyssomicin Y is a type I abyssomicin with an epoxide group at C-8 and C-9. Compounds 1–3 showed potent inhibitory effects against the influenza A virus; their observed inhibition rates were 97.9%, 98.3%, and 95.9%, respectively, at a concentration of 10 μM, and they displayed lower cytotoxicity than 4. The structures were determined by different NMR techniques and HRMS experiments. This investigation revealed that OSMAC could serve as a useful method for enabling the activation of the silent genes in the microorganism and for the formation of previously unreported active secondary metabolites.

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Funding

This work was partially supported by the grants from the National Natural Science Foundation of China (31430002, 31720103901, 21877038, 81573341, 21877124, 31320103911, 31670052), Taishan Scholarship, Open Project Funding of the State Key Laboratory of Bioreactor Engineering, the 111 Project (B18022), and the Fundamental Research Funds for the Central Universities (22221818014).

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Jingyu Zhang and Bixiao Li contributed equally to this work.

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State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China
Jingyu Zhang, Bixiao Li, Loganathan Karthik, Guoliang Zhu, Chengjian Hou, Lan Jiang, Lixin Zhang & Xueting Liu
Institute of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui Province, China
Bixiao Li
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China
Bixiao Li, Yujie Qin, Xin Ye, Mei Liu & Huanqin Dai
Sri Shakthi Institute of Engineering and Technology (Autonomous), Coimbatore, Tamil Nadu, India
Loganathan Karthik
Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD, 4111, Australia
Miaomiao Liu
School of Environmental Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
Tom Hsiang

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Jingyu Zhang
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Bixiao Li
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Yujie Qin
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Mei Liu
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Huanqin Dai
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Zhang, J., Li, B., Qin, Y. et al. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137. Appl Microbiol Biotechnol 104, 1533–1543 (2020). https://doi.org/10.1007/s00253-019-10217-2

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Received: 07 August 2019
Revised: 16 October 2019
Accepted: 22 October 2019
Published: 02 January 2020
Issue Date: February 2020
DOI: https://doi.org/10.1007/s00253-019-10217-2

Keywords

Abyssomicin
Proximicin
Marine-derived Verrucosispora sp.
OSMAC
Anti-influenza A virus