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Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus


The worldwide prevalence of type 2 diabetes mellitus (T2DM) is constantly increasing, and it has become a major concern, with several implications for public health, economy, and social well-being. It is well-known that several factors such as lifestyle, increased intake of fat and sugar-rich foods, and host genetics can lead to T2DM. Some recent studies have suggested that the composition of the intestinal microbiota can trigger T2DM. Since then, considerable effort has been made to understand the link between the composition of intestinal microbiota and T2DM, as well as the role of probiotics in modulation of intestinal microbiota. This mini-review summarizes the major findings and discusses the close relationship between intestinal microbiota, probiotics, and T2DM.

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The authors wish to thank Lucas A.R. Tannuri for drawing and editing the figure shown in this article.


This work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq).

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Correspondence to Katia Sivieri.

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Salgaço, M.K., Oliveira, L.G.S., Costa, G.N. et al. Relationship between gut microbiota, probiotics, and type 2 diabetes mellitus. Appl Microbiol Biotechnol 103, 9229–9238 (2019).

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  • Type 2 diabetes
  • Gut microbiota
  • Probiotic
  • Chronic disease