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Origination, change, and modulation of geriatric disease-related gut microbiota during life


The age-related changes in the diversity and composition of the gut microbiota are well described in recent studies. These changes have been suggested to be influenced by age-associated weakening of the immune system and low-grade chronic inflammation, resulting in numerous age-associated pathological conditions. Gut microbiota homeostasis is important throughout the life of the host by providing vital functions to regulate various immunological functions and homeostasis. Based on published results, we summarize the relationship between the gut microbiota and aging-related diseases, especially Parkinson’s disease, immunosenescence, rheumatoid arthritis, bone loss, and metabolic syndrome. The change in composition of the gut microbiota and gut ecosystem during life and its influence on the host immunologic and metabolic phenotype are also analyzed to determine factors that affect aging-related diseases. Approaches to maintain host health and prevent or cure geriatric diseases are also discussed.

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This study was supported by the National Key Technology R&D Program (grant number 2015BAD16B02), the Modern Agricultural Industry Technology System (CARS-30), Key Research and Development Plan of Shaanxi Province (2017ZDXL-NY-0304), and National Natural Science Foundation of China (NSFC) (grant Number 31701722 and 3147171).

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Muhammad Shahid Riaz Rajoka and Junling Shi wrote the review. All authors reviewed the manuscript.

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Correspondence to Junling Shi.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Riaz Rajoka, M.S., Zhao, H., Li, N. et al. Origination, change, and modulation of geriatric disease-related gut microbiota during life. Appl Microbiol Biotechnol 102, 8275–8289 (2018).

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  • Gut microbiota
  • Immunity
  • Dysbiosis
  • Disorder
  • Health span
  • Aging
  • Elderly