Applied Microbiology and Biotechnology

, Volume 102, Issue 9, pp 3951–3965 | Cite as

The features that distinguish lichenases from other polysaccharide-hydrolyzing enzymes and the relevance of lichenases for biotechnological applications

  • Irina V. Goldenkova-Pavlova
  • Alexander А. Tyurin
  • Orkhan N. Mustafaev


The main specific features of β-1,3-1,4-glucanases (or lichenases, EC, the enzymes that in a strictly specific manner hydrolyze β-glucans of many cereal species and lichens containing β-1,3 and β-1,4 bonds, are reviewed as well as the current strategies used for their protein design, which have been successfully applied to make lichenases more attractive and promising for biocatalytic conversion of biomass, in particular, in the areas of their biotechnological application, such as brewing industry, animal feed manufacture, and biofuel production, which will in future allow these technologies to be economically and ecologically beneficial.


Lichenase Properties Structure Stability Protein design Biotechnological application 



The work was supported by the Russian Foundation for Basic Research (project no. 16-34-00249; AAT).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This work does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Irina V. Goldenkova-Pavlova
    • 1
    • 2
  • Alexander А. Tyurin
    • 1
    • 2
  • Orkhan N. Mustafaev
    • 3
  1. 1.Institute of Plant PhysiologyRussian Academy of SciencesMoscowRussia
  2. 2.Department of Genetics and BiotechnologyRussian State Agrarian University–Moscow Timiryazev Agricultural AcademyMoscowRussia
  3. 3.Department of Biophysics and Molecular BiologyBaku State UniversityBakuAzerbaijan

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