(Some) current concepts in antibacterial drug discovery

van Geelen, Lasse; Meier, Dieter; Rehberg, Nidja; Kalscheuer, Rainer

doi:10.1007/s00253-018-8843-6

Mini-Review
Published: 17 February 2018

(Some) current concepts in antibacterial drug discovery

Lasse van Geelen¹^na1,
Dieter Meier¹^na1,
Nidja Rehberg¹^na1 &
Rainer Kalscheuer ORCID: orcid.org/0000-0002-3378-2067¹

Applied Microbiology and Biotechnology volume 102, pages 2949–2963 (2018)Cite this article

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Abstract

The rise of multidrug resistance in bacteria rendering pathogens unresponsive to many clinical drugs is widely acknowledged and considered a critical global healthcare issue. There is broad consensus that novel antibacterial chemotherapeutic options are extremely urgently needed. However, the development pipeline of new antibacterial drug lead structures is poorly filled and not commensurate with the scale of the problem since the pharmaceutical industry has shown reduced interest in antibiotic development in the past decades due to high economic risks and low profit expectations. Therefore, academic research institutions have a special responsibility in finding novel treatment options for the future. In this mini review, we want to provide a broad overview of the different approaches and concepts that are currently pursued in this research field.

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Funding

Work in the Kalscheuer laboratory related to this topic is funded by the German Research Foundation (DFG) research training group GRK 2158, the Federal Ministry of Education and Research BMBF (16GW0109), and the Juergen Manchot Foundation (MOI III Graduate School).

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Lasse van Geelen, Dieter Meier and Nidja Rehberg contributed equally to this work.

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Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University Düsseldorf, 40225, Dusseldorf, Germany
Lasse van Geelen, Dieter Meier, Nidja Rehberg & Rainer Kalscheuer

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Lasse van Geelen
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Dieter Meier
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Nidja Rehberg
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Rainer Kalscheuer
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Correspondence to Rainer Kalscheuer.

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van Geelen, L., Meier, D., Rehberg, N. et al. (Some) current concepts in antibacterial drug discovery. Appl Microbiol Biotechnol 102, 2949–2963 (2018). https://doi.org/10.1007/s00253-018-8843-6

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Received: 04 December 2017
Revised: 05 February 2018
Accepted: 06 February 2018
Published: 17 February 2018
Issue Date: April 2018
DOI: https://doi.org/10.1007/s00253-018-8843-6

Keywords

Antibiotic
Pathogen
Endophyte
Myxobacteria
Marine invertebrate
Drug conjugate