Applied Microbiology and Biotechnology

, Volume 103, Issue 6, pp 2449–2467 | Cite as

Oxetane-containing metabolites: origin, structures, and biological activities

  • Vera Vil
  • Alexander O. Terent’ev
  • Abed Al Aziz Al Quntar
  • Tatyana A. Gloriozova
  • Nick Savidov
  • Valery M. DembitskyEmail author


Cyclobutanes containing one oxygen atom in a molecule are called oxetane-containing compounds (OCC). More than 600 different OCC are found in nature; they are produced by microorganisms, and also found in marine invertebrates and algae. The greatest number of them is found in plants belonging to the genus Taxus. Oxetanes are high-energy oxygen-containing non-aromatic heterocycles that are of great interest as new potential pharmacophores with a significant spectrum of biological activities. The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, antiviral (arbovirus), and antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity dominate with confidence from 81 to 99%.


Oxetane Cyclobutane Microorganisms Fungi Algae Invertebrates Plant Activities 



The work was performed in the framework of the Program for Basic Research of Russian State Academies of Sciences (RFBR; Vera Vil’s student project no. 18-33-00651).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Vera Vil
    • 1
  • Alexander O. Terent’ev
    • 1
  • Abed Al Aziz Al Quntar
    • 2
  • Tatyana A. Gloriozova
    • 3
  • Nick Savidov
    • 4
  • Valery M. Dembitsky
    • 1
    • 4
    • 5
    Email author
  1. 1.N.D. Zelinsky Institute of Organic ChemistryRussian Academy of SciencesMoscowRussia
  2. 2.Department of Material EngineeringFaculty of Engineering, Al Quds UniversityJerusalemIsrael
  3. 3.Institute of Biomedical ChemistryMoscowRussia
  4. 4.Centre for Applied Research and InnovationLethbridge CollegeLethbridgeCanada
  5. 5.Biochemical LabNational Scientific Center of Marine BiologyVladivostokRussia

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