Biological activity of lipopeptides from Bacillus
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The lipopeptides of Bacillus are small metabolites that contain a cyclic structure formed by 7–10 amino acids (including 2–4 d-amino acids) and a beta-hydroxy fatty acid with 13–19 C atoms. These lipopeptides exhibit a variety of biological activities, including interactions with biofilms, and anti-fungal, anti-inflammatory, anti-tumor, anti-virus, and anti-platelet properties. The multiple activities of lipopeptides have stimulated significant interest in the exploitation of these lipopeptides for use as antibiotics, feed additives, anti-tumor agents, urgent thrombolytic therapeutic agents, and drug delivery systems. Understanding the natural function of these structurally diverse lipopeptides in Bacillus provides insight into microbial regulatory programs and is required for efficient development of more effective products. Currently, there is still insufficient knowledge of the direct target of these lipopeptides, and continued efforts are needed to enhance their biosynthesis efficiency for industrial applications.
KeywordsBacillus subtilis Lipopeptide Surfactin Iturin Fengycin
This review was supported by the National Science-Technology Support Plan Projects (No. 2015BAD16B02), the National Natural Science Fund (Grant No. 31471718), the Agriculture Department of China (Grant No. CARS-30), and the Northwestern Polytechnical University (No. 3102014JCQ15011 and No. 3102014GEKY1010).
Haobin Zhao and Junling Shi were responsible for writing the review. Muhammad Shahid Riaz Rajoka assisted in revising the article. Dongyan Shao and Chunming Jiang assisted in providing references for the manuscript. Qi Li, Qinsheng Huang, Hui Yang, and Mingliang Jin did the final proofreading of the manuscript. All authors reviewed the manuscript.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- Chen Y, Yan F, Chai Y, Liu H, Kolter R, Losick R, Guo JH (2013) Biocontrol of tomato wilt disease by Bacillus subtilis isolates from natural environments depends on conserved genes mediating biofilm formation. Environ Microbiol 15(3):848–864. doi: 10.1111/j.1462-2920.2012.02860.x CrossRefPubMedGoogle Scholar
- Cho KM, Math RK, Hong SY, Asraful Islam SM, Mandanna DK, Cho JJ, Yun MG, Kim JM, Yun HD (2009) Iturin produced by Bacillus pumilus HY1 from Korean soybean sauce (kanjang) inhibits growth of aflatoxin producing fungi. Food Control 20(4):402–406. doi: 10.1016/j.foodcont.2008.07.010 CrossRefGoogle Scholar
- Comella N, Grossman AD (2005) Conservation of genes and processes controlled by the quorum response in bacteria: characterization of genes controlled by the quorum-sensing transcription factor ComA in Bacillus subtilis. Mol Microbiol 57(4):1159–1174. doi: 10.1111/j.1365-2958.2005.04749.x CrossRefPubMedGoogle Scholar
- Coutte F, Leclere V, Bechet M, Guez JS, Lecouturier D, Chollet-Imbert M, Dhulster P, Jacques P (2010) Effect of pps disruption and constitutive expression of srfA on surfactin productivity, spreading and antagonistic properties of Bacillus subtilis 168 derivatives. J Appl Microbiol 109(2):480–491. doi: 10.1111/j.1365-2672.2010.04683.x PubMedGoogle Scholar
- Han Q, Wu F, Wang X, Qi H, Shi L, Ren A, Liu Q, Zhao M, Tang C (2015) The bacterial lipopeptide iturins induce Verticillium dahliae cell death by affecting fungal signalling pathways and mediate plant defence responses involved in pathogen-associated molecular pattern-triggered immunity. Environ Microbiol 17(4):1166–1188. doi: 10.1111/1462-2920.12538 CrossRefPubMedGoogle Scholar
- Huang X, Lu Z, Zhao H, Bie X, Lü FX, Yang S (2006) Antiviral activity of antimicrobial lipopeptide from Bacillus subtilis fmbj against Pseudorabies virus, Porcine Parvovirus, Newcastle Disease virus and Infectious Bursal Disease virus in vitro. Int J Pept Res Ther 12(4):373–377. doi: 10.1007/s10989-006-9041-4 CrossRefGoogle Scholar
- Hwang MH, Lim JH, Yun HI, Rhee MH, Cho JY, Hsu WH, Park SC (2005) Surfactin C inhibits the lipopolysaccharide-induced transcription of interleukin-1beta and inducible nitric oxide synthase and nitric oxide production in murine RAW 264.7 cells. Biotechnol Lett 27(20):1605–1608. doi: 10.1007/s10529-005-2515-1 CrossRefPubMedGoogle Scholar
- Kim SY, Kim JY, Kim SH, Bae HJ, Yi H, Yoon SH, Koo BS, Kwon M, Cho JY, Lee CE, Hong S (2007) Surfactin from Bacillus subtilis displays anti-proliferative effect via apoptosis induction, cell cycle arrest and survival signaling suppression. FEBS Lett 581(5):865–871. doi: 10.1016/j.febslet.2007.01.059 CrossRefPubMedGoogle Scholar
- Koglin A, Lohr F, Bernhard F, Rogov VV, Frueh DP, Strieter ER, Mofid MR, Guntert P, Wagner G, Walsh CT, Marahiel MA, Dotsch V (2008) Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 454(7206):907–911. doi: 10.1038/nature07161 CrossRefPubMedPubMedCentralGoogle Scholar
- Lee JH, Nam SH, Seo WT, Yun HD, Hong SY, Kim MK, Cho KM (2012) The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells. Food Chem 131(4):1347–1354. doi: 10.1016/j.foodchem.2011.09.133 CrossRefGoogle Scholar
- Myoungseok K, Jonghwan L, Byungkwon P, Yunhwan H, Song IB, Seungchun P, Yun HI (2009) Effect of surfactin on growth performance of weaning piglets in combination with Bacillus subtilis BC1212, vol 26,Google Scholar
- Xu HM, Rong YJ, Zhao MX, Song B, Chi ZM (2014) Antibacterial activity of the lipopetides produced by Bacillus amyloliquefaciens M1 against multidrug-resistant Vibrio spp. isolated from diseased marine animals. Appl Microbiol Biotechnol 98(1):127–136. doi: 10.1007/s00253-013-5291-1 CrossRefPubMedGoogle Scholar
- Zeriouh H, Romero D, Garcia-Gutierrez L, Cazorla FM, de Vicente A, Perez-Garcia A (2011) The iturin-like lipopeptides are essential components in the biological control arsenal of Bacillus subtilis against bacterial diseases of cucurbits. Mol Plant-Microbe Interact 24(12):1540–1552. doi: 10.1094/MPMI-06-11-0162 CrossRefPubMedGoogle Scholar