Recent advances in biotechnological applications of alcohol dehydrogenases

Abstract

Alcohol dehydrogenases (ADHs), which belong to the oxidoreductase superfamily, catalyze the interconversion between alcohols and aldehydes or ketones with high stereoselectivity under mild conditions. ADHs are widely employed as biocatalysts for the dynamic kinetic resolution of racemic substrates and for the preparation of enantiomerically pure chemicals. This review provides an overview of biotechnological applications for ADHs in the production of chiral pharmaceuticals and fine chemicals.

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Acknowledgments

The Research Project of the National Natural Science Foundation of China (no. 21672190) and the Major Program for Key Science and Technology of Zhejiang Province of China (no. 2014C03010) are gratefully acknowledged for providing financial support.

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Correspondence to Yu-Guo Zheng or Zhi-Qiang Liu.

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Zheng, YG., Yin, HH., Yu, DF. et al. Recent advances in biotechnological applications of alcohol dehydrogenases. Appl Microbiol Biotechnol 101, 987–1001 (2017). https://doi.org/10.1007/s00253-016-8083-6

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Keywords

  • Alcohol dehydrogenases
  • Biotechnological applications
  • Chiral pharmaceuticals
  • Fine chemicals