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Isomerases for biotransformation of D-hexoses

Applied Microbiology and Biotechnology volume 99, pages 6571–6584 (2015)Cite this article

Abstract

Monosaccharides are polyhydroxyl compounds containing several chiral carbons, giving rise to tens of isomeric forms. Only minority of them are natural carbohydrates existing in nature abundantly, and most of them are rarely in nature, called rare sugars. These rare sugars attract increasing attention because of their low-calorie property and promising beneficial effects. Izumoring strategy has been established for linking all monosaccharides by three types of enzymes including ketose 3-epimerases, polyol dehydrogenases, and aldose isomerases. Recently, more attention has been paid on the Izumoring of hexoses, especially the D-zone hexoses. So far, at least ten isomerases have been used for the isomerization reactions between D-aldohexoses and D-ketohexoses. In this article, the interconnections and potential physiological effects of D-ketohexoses and D-aldohexoses are summarized, the D-zone hexose Izumoring is shown by giving the exact biocatalysts, and importantly, the isomerases for D-hexose biotransformation are reviewed in detail.

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Acknowledgments

This work was supported by the NSFC Project (Nos. 21276001 and 31171705), the 863 Project (No. 2013AA102102), the Fundamental Research Funds for the Central Universities (No. JUSRP51304A), and the Support Project of Jiangsu Province (No. BK20130001).

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Authors and Affiliations

  1. State Key Laboratory of Food Science and Technology, Ministry of Education, Key Laboratory of Carbohydrate Chemistry and Biotechnology, Jiangnan University, Wuxi, Jiangsu, 214122, China

    Wanmeng Mu, Lina Yu, Wenli Zhang, Tao Zhang & Bo Jiang

  2. Synergetic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi, 214122, China

    Wanmeng Mu & Bo Jiang

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  1. Wanmeng Mu
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  2. Lina Yu
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  3. Wenli Zhang
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  4. Tao Zhang
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  5. Bo Jiang
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Correspondence to Wanmeng Mu.

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Mu, W., Yu, L., Zhang, W. et al. Isomerases for biotransformation of D-hexoses. Appl Microbiol Biotechnol 99, 6571–6584 (2015). https://doi.org/10.1007/s00253-015-6788-6

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  • DOI: https://doi.org/10.1007/s00253-015-6788-6

Keywords

  • Aldose isomerase
  • Biotransformation
  • Hexose
  • Monosaccharide
  • Rare sugar