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Nicotine-degrading microorganisms and their potential applications

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Abstract

Nicotine-degrading microorganisms (NDMs) are a special microbial group which can use nicotine as the sole carbon and nitrogen source for growth. Since the 1950s, the bioconversion of nicotine by microbes has received increasing attention, and several NDMs have been identified, such as Arthrobacter nicotinovorans, Microsporum gypseum, Pellicularia filamentosa JTS-208, and Pseudomonas sp. 41. In recent years, increasing numbers of NDMs have been isolated and identified from tobacco plantation soil, leaf, and tobacco waste. Meanwhile, the metabolic pathway and degradation mechanism of nicotine have been elucidated in several NDMs, such as A. nicotinovorans, Agrobacterium tumefaciens S33, Aspergillus oryzae, and Pseudomonas putida S16. Moreover, several NDMs have been used in improving the quality of cigarettes, treating tobacco waste, and producing valuable intermediates of nicotine. Here, we summarize the diversity, phylogenetic analysis, and potential applications of NDMs.

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Acknowledgments

We are grateful to Prof. Jianping Xu of the Dept. of Biology, McMaster University for valuable comments and critical discussions. This work was supported by the Science and Technology Program of Chongqing Tobacco Company (approval no. NY20120802070020), the National Natural Science Foundation of China (31060012), and the Program for Excellent Young Talents of Yunnan University (To Jinkui Yang). We also thank the anonymous reviewers for their useful suggestions.

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Authors and Affiliations

  1. Tobacco Company of Chongqing, Chongqing, 400023, People’s Republic of China

    Jianli Liu & Tao Chen

  2. Yunnan Comtestor Co. Ltd., Kunming, 650106, People’s Republic of China

    Guanghui Ma, Ying Hou & Shihua Yang

  3. Laboratory for Conservation and Utilization of Bio-Resources, Yunnan University, Kunming, 650091, People’s Republic of China

    Ke-Qin Zhang & Jinkui Yang

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  1. Jianli Liu
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  2. Guanghui Ma
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  3. Tao Chen
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  5. Shihua Yang
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  6. Ke-Qin Zhang
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  7. Jinkui Yang
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Correspondence to Jinkui Yang.

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Jinkui Yang holds a Ph.D., Yunnan University.

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Liu, J., Ma, G., Chen, T. et al. Nicotine-degrading microorganisms and their potential applications. Appl Microbiol Biotechnol 99, 3775–3785 (2015). https://doi.org/10.1007/s00253-015-6525-1

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