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Beneficial effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products

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Abstract

It is well-known that probiotics have a number of beneficial health effects in humans and animals, including the reduction of symptoms in lactose intolerance and enhancement of the bioavailability of nutrients. Probiotics have showed to possess antimutagenic, anticarcinogenic and hypocholesterolemic properties. Further, they were also observed to have antagonistic actions against intestinal and food-borne pathogens, to decrease the prevalence of allergies in susceptible individuals and to have immunomodulatory effects. Typically, the bacteria colonise the intestinal tract first and then reinforce the host defence systems by inducing a generalised mucosal immune response, balanced T-helper cell response, self-limited inflammatory response and secretion of polymeric IgA. Scientific reports showed that the Taiwan native lactic acid bacterium from newborn infant faeces identified as Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products proved to be effective for the management of blood cholesterol and pressure, prevention of gastric mucosal lesion development, immunomodulation and alleviation of allergies, anti-osteoporosis and inhibition the fat tissue accumulation. This review article describes that the beneficial effects of this Lactobacillus strains and derivative products may be suitable for human and animals.

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References

  • Ahrne S, Nobaek S, Jeppsson B, Adlerberth I, Wold AE, Molin G (1998) The normal Lactobacillus flora of healthy human rectal and oral mucosa. J Appl Microbiol 85:88–94

    Article  CAS  Google Scholar 

  • Bae EA, Min SW, Lee B, Kim NJ, Baek NI, Han EJ, Chung HG, Kim DH (2007) Antiasthmic effect of fermented Artemisia princeps in asthmic mice induced by ovalbumin. J Microbiol Biotechnol 17:1554–1557

    CAS  Google Scholar 

  • Bray G (2004) A medical consequences of obesity. J Clin Endocrinol Metab 89:2583–2589

    Article  CAS  Google Scholar 

  • Candore G, Colonna-Romano G, Balistreri CR, Di Carlo D, Grimaldi MP, Listì F, Nuzzo D, Vasto S, Lio D, Caruso C (2006) Biology of longevity: role of the innate immune system. Rejuv Res 9:143–148

    Article  CAS  Google Scholar 

  • Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listì F, Scola L, Vasto S, Caruso C (2008) Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuv Res 11:425–432

    Article  CAS  Google Scholar 

  • Cani PD, Delzenne NM (2009) The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des 15:1546–1558

    Article  CAS  Google Scholar 

  • Caridi A (2002) Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei. J Ind Microbiol Biotechnol 29:303–308

    Article  CAS  Google Scholar 

  • Castillo NA, Perdigón G, de Moreno de Leblanc A (2011) Oral administration of a probiotic Lactobacillus modulates cytokine production and TLR expression improving the immune response against Salmonella enterica serovar Typhimurium infection in mice. BMC Microbiol 11:177

    Article  CAS  Google Scholar 

  • Chiang SS (2011) The allergenicity assessment of Lactococcus lactis NZ9000/pNZPNK and evaluation of the probiotic effects on Lactobacillus paracasei subsp. paracasei NTU 101 and Lactobacillus plantarum NTU 102. Ph.D. dissertation, National Taiwan University, Taipei, Taiwan

  • Chiang SS, Pan TM (2011) Antiosteoporotic effects of lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomised mice. J Agric Food Chem 59:7734–7742

    Article  CAS  Google Scholar 

  • Chiang SS, Liao JW, Pan TM (2011a) Effect of bioactive compounds in lactobacilli-fermented soy skim milk on femoral bone microstructure of aging mice. J Sci Food Agric. doi:10.1002/jsfa.4579

  • Chiang SS, Liu CF, Tseng KC, Mau JL, Pan TM (2011b) Immunomodulatory effects of dead Lactobacillus on murine splenocytes and macrophages. Food Agr Immunol. doi:10.1080/09540105.2011.609246

  • Chiu CH, Lu TY, Tseng YY, Pan TM (2006) The effects of Lactobacillus-fermented milk on lipid metabolism in hamsters fed on high-cholesterol diet. Appl Microbiol Biotechnol 71:238–245

    Article  CAS  Google Scholar 

  • Choi I, Kim Y, Park Y, Seog H, Choi H (2007) Anti-obesity activities of fermented soygerm isoflavones by Bifidobacterium breve. Biofactors 29:105–112

    Article  CAS  Google Scholar 

  • de Vrese M, Schrezenmeir J (2008) Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 111:1–66

    Google Scholar 

  • Egermann M, Goldhahn J, Schneider E (2005) Animal models for fracture treatment in osteoporosis. Osteoporosis Int 16:S129–S138

    Article  Google Scholar 

  • Enomoto M, Noguchi S, Hattori M, Sugiyama H, Suzuki Y, Hanaoka A, Okada S, Yoshida T (2009) Oral administration of Lactobacillus plantarum NRIC0380 suppresses IgE production and induces CD4(+)CD25(+)Foxp3(+) cells in vivo. Biosci Biotechnol Biochem 73:457–460

    Article  CAS  Google Scholar 

  • Flegal KM, Carroll MD, Ogden CL, Curtin LR (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303:235–241

    Article  CAS  Google Scholar 

  • Fooks LJ, Fuller R, Gibson GR (1999) Prebiotics, probiotics and human gut microbiology. Int Dairy J 9:53–61

    Article  Google Scholar 

  • Fuglsang A, Nilsson D, Nyborg NC (2002) Cardiovascular effects of fermented milk containing angiotensin-converting enzyme inhibitors evaluated in permanently catheterised, spontaneously hypertensive rats. Appl Environ Microbiol 68:3566–3569

    Article  CAS  Google Scholar 

  • Fujimura S, Kato S, Oda M, Miyahara M, Ito Y, Kimura K, Kawamura T, Ohnuma M, Tateno H, Watanabe A (2006) Detection of Lactobacillus gasseri OLL2716 strain administered with yogurt drink in gastric mucus layer in humans. Lett Appl Microbiol 43:578–581

    Article  CAS  Google Scholar 

  • Fujiwara D, Inoue S, Wakabayashi H, Fujii T (2004) The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance. Int Arch Allergy Immunol 135:205–215

    Article  CAS  Google Scholar 

  • Fukushima M, Nakano M (1996) Effects of mixture of organisms, Lactobacillus acidophilus or Streptococcus faecalis on cholesterol metabolism in rats fed on a fat- and cholesterol-enriched diet. Br J Nutr 76:857–867

    Article  CAS  Google Scholar 

  • Glavin GB, Szabo S (1992) Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies. FASEB J 6:825–831

    CAS  Google Scholar 

  • Guo Y, Wu G, Su X, Yang H, Zhang J (2009) Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet. Nutrition Res 29:656–663

    Article  CAS  Google Scholar 

  • Harmon AW, Harp JB (2001) Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol 280:807–813

    Google Scholar 

  • Hata Y, Yamamoto M, Ohni M, Nakajima K, Nakamura Y, Takano T (1996) A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 64:767–771

    CAS  Google Scholar 

  • Hayflick L (2007) Biological aging is no longer an unsolved problem. Ann NY Acad Sci 1100:1–13

    Article  CAS  Google Scholar 

  • Holzapfel WH (2006) Introduction to prebiotics and probiotics. In: Goktepe et al (eds) Probiotics in food safety and human health. CRC (Taylor & Francis Group), Boca Raton, pp 1–33

    Google Scholar 

  • Hougee S, Vriesema AJ, Wijering SC, Knippels LM, Folkerts G, Nijkamp FP, Knol J, Garssen J (2010) Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitised mice: a bacterial strain comparative study. Int Arch Allergy Immunol 151:107–117

    Article  CAS  Google Scholar 

  • Imig JD (2004) ACE inhibition and bradykinin-mediated renal vascular responses: EDHF involvement. Hypertension 43:533–535

    Article  CAS  Google Scholar 

  • Ishida-Fujii K, Goto S, Kuboki H, Hirano S, Sakamoto M, Sato M (2004) Isolation and identification of lactic acid bacteria with effect of immune protection to Escherichia coli in mice. Biofactors 21:155–158

    Article  CAS  Google Scholar 

  • Ivanova K, Marina M, Petrov P, Kantardjiev T (2010) Campylobacteriosis and other bacterial gastrointestinal diseases in Sofia, Bulgaria for the period 1987–2008. Euro Surveill 15:19474

    CAS  Google Scholar 

  • Jauhiainen T, Korpela R (2007) Milk peptides and blood pressure. J Nutr 137:825S–829S

    CAS  Google Scholar 

  • Jauhiainen T, Rönnback M, Vapaatalo H, Wuolle K, Kautiainen H, Groop PH, Korpela R (2010) Long-term intervention with Lactobacillus helveticus fermented milk reduces augmentation index in hypertensive subjects. Eur J Clin Nutr 64:424–431

    Article  CAS  Google Scholar 

  • Kadooka Y, Sato M, Imaizumi K, Ogawa A, Ikuyama K, Akai Y, Okano M, Kagoshima M, Tsuchida T (2010) Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomised controlled trial. Eur J Clin Nutr 64:636–643

    Article  CAS  Google Scholar 

  • Kapila S, Sinha PR (2006) Antioxidative and hypocholesterolemic effect of Lactobacillus casei subsp casei (biodefensive properties of lactobacilli). Indian J Med Sci 60:361–370

    Article  Google Scholar 

  • Karch H, Tarr P, Bielaszewska M (2005) Enterohaemorrhagic Escherichia coli in human medicine. Int J Med Microbiol 295:405–418

    Article  CAS  Google Scholar 

  • Kim JY, Choil YO, Ji GE (2008a) Effect of oral probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) administration on ovalbumin-induced food allergy mouse model. J Microbiol Biotechnol 18:1393–1400

    CAS  Google Scholar 

  • Kim NH, Moon PD, Kim SJ, Choi IY, An HJ, Myung NY, Jeong HJ, Um JY, Hong SH, Kim HM (2008b) Lipid profile lowering effect of Soypro™ fermented with lactic acid bacteria isolated from Kimchi in high-fat diet-induced obese rats. Biofactors 33:49–60

    Article  CAS  Google Scholar 

  • Kondo S, Xiao JZ, Satoh T, Odamaki T, Takahashi S, Sugahara H, Yaeshima T, Iwatsuki K, Kamei A, Abe K (2010) Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem 74:1656–1661

    Article  CAS  Google Scholar 

  • Lam EK, Tai EK, Koo MW, Wong HP, Wu WK, Yu L, So WH, Woo PC, Cho CH (2007a) Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG. Life Sci 80:2128–2136

    Article  CAS  Google Scholar 

  • Lam EK, Yu L, Wong HP, Wu WK, Shin VY, Tai EK, So WH, Woo PC, Cho CH (2007b) Probiotic Lactobacillus rhamnosus GG enhances gastric ulcer healing in rats. Eur J Pharmacol 565:171–179

    Article  CAS  Google Scholar 

  • Lee HY, Park JH, Seok SH, Baek MW, Kim DJ, Lee KE, Paek KS, Lee Y, Park JH (2006) Human originated bacteria, Lactobacillus rhamnosus PL60, produce conjugated linoleic acid and show anti-obesity effects in diet-induced obese mice. Biochim Biophys Acta 1761:736–744

    CAS  Google Scholar 

  • Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci 102:11070–11075

    Article  CAS  Google Scholar 

  • Lin FM, Chiu CH, Pan TM (2004) Fermentation of a milk–soymilk and Lycium chinense miller mixture using a new isolate of Lactobacillus paracasei subsp. paracasei NTU 101 and Bifidobacterium longum. J Ind Microbiol Biotechnol 31:559–564

    Article  CAS  Google Scholar 

  • Liu CF, Hu CL, Chiang SS, Tseng KC, Yu RC, Pan TM (2009) Beneficial preventive effects of gastric mucosal lesion for soy–skim milk fermented by lactic acid bacteria. J Agric Food Chem 57:4433–4438

    Article  CAS  Google Scholar 

  • Liu CF, Tseng KC, Chiang SS, Lee BH, Hsu WH, Pan TM (2011a) Immunomodulatory and antioxidant potential of Lactobacillus exopolysaccharides. J Sci Food Agric 91:2284–2291

    CAS  Google Scholar 

  • Liu CF, Tung YT, Wu CL, Lee BH, Hsu WH, Pan TM (2011b) Antihypertensive effects of Lactobacillus-fermented milk orally administered to spontaneously hypertensive rats. J Agric Food Chem 59:4537–4543

    Article  CAS  Google Scholar 

  • Lo YH (2011) The effect of Lactobacillus paracasei subsp. paracasei NTU 101 and Lactobacillus plantarum NTU 102 prevent the development of obesity and inflammatory response induced by high-fat diet. Master dissertation, National Taiwan University, Taipei, Taiwan

  • Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303:1662–1665

    Article  CAS  Google Scholar 

  • Maragkoudakis PA, Chingwaru W, Gradisnik L, Tsakalidou E, Cencic A (2010) Lactic acid bacteria efficiently protect human and animal intestinal epithelial and immune cells from enteric virus infection. Int J Food Microbiol 141:S91–S97

    Article  Google Scholar 

  • Medeiros KC, Figueiredo CA, Figueredo TB, Freire KR, Santos FA, Alcantara-Neves NM, Silva TM, Piuvezam MR (2008) Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitised mice. J Ethnopharmacol 119:41–46

    Article  CAS  Google Scholar 

  • Ménard S, Heyman M (2006) Modulation of epithelial function and local immune system by probiotics: mechanisms involved. In: Goktepe et al (eds) Probiotics in food safety and human health. CRC (Taylor & Francis Group), Boca Raton, pp 341–363

    Google Scholar 

  • Moran AP (2010) The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni. Subcell Biochem 53:209–240

    Article  CAS  Google Scholar 

  • Narva M, Collin M, Lamberg-Allardt C, Kärkkäinen M, Poussa T, Vapaatalo H, Korpela R (2004) Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats. Ann Nutr Metab 48:228–234

    Article  CAS  Google Scholar 

  • National Osteoporosis Foundation (NOF) (2010) Clinician’s guide to prevention and treatment of osteoporosis. National Osteoporosis Foundation, Washington, DC

    Google Scholar 

  • Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC (2009) Mechanisms of action of probiotics: recent advances. Inflamm Bowel Dis 15:300–310

    Article  CAS  Google Scholar 

  • Noh DO, Kim SH, Gilliland SE (1997) Incorporation of cholesterol into the cellular membrane of Lactobacillus acidophilus ATCC 43121. J Dairy Sci 80:3107–3113

    Article  CAS  Google Scholar 

  • Nonaka Y, Izumo T, Izumi F, Maekawa T, Shibata H, Nakano A, Kishi A, Akatani K, Kiso Y (2008) Antiallergic effects of Lactobacillus pentosus strain S-PT84 mediated by modulation of Th1/Th2 immunobalance and induction of IL-10 production. Int Arch Allergy Immunol 145:249–257

    Article  Google Scholar 

  • Ohashi Y, Ushida K (2009) Health-beneficial effects of probiotics: its mode of action. Anim Sci J 80:361–371

    Article  Google Scholar 

  • Ouwehand AC (2007) Antiallergic effects of probiotics. J Nutr 137:794S–797S

    CAS  Google Scholar 

  • Pan TM, Chiu CH, Guu YK (2002) Characterization of Lactobacillus isolates from pickled vegetables for use as dietary or pickle adjuncts. Foods & Food Ingred J Jpn 206:45–51

    CAS  Google Scholar 

  • Perdigon G, Vintini E, Alvarez S, Medina M, Medici M (1999) Study of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria. J Dairy Sci 82:1108–1114

    Article  CAS  Google Scholar 

  • Pietschmann P, Rauner M, Sipos W, Kerschan-Schindl K (2009) Osteoporosis: an age-related and gender-specific disease—a mini-review. Gerontology 55:3–12

    Article  Google Scholar 

  • Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH (2006) Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol 26:968–976

    Article  CAS  Google Scholar 

  • Romeo J, Nova E, Warnberg J, Gomez-Martinez S, Diaz Ligia LE, Marcos A (2010) Immunomodulatory effect of fibres, probiotics and synbiotics in different life-stages. Nutr Hosp 25:341–349

    CAS  Google Scholar 

  • Sakamoto I, Igarashi M, Kimura K, Takagi A, Miwa T, Koga Y (2001) Suppressive effect of Lactobacillus gasseri OLL 2716 (LG21) on Helicobacter pylori infection in humans. J Antimicrob Chemother 47:709–710

    Article  CAS  Google Scholar 

  • Sashihara T, Sueki N, Ikegami S (2006) An analysis of the effectiveness of heat-killed lactic acid bacteria in alleviating allergic diseases. J Dairy Sci 89:2846–2855

    Article  CAS  Google Scholar 

  • Schmid K, Schlothauer RC, Friedrich U, Staudt C, Apajalahti J, Hansen EB (2006) Development of probiotic food ingredients. In: Goktepe et al (eds) Probiotics in food safety and human health. CRC (Taylor & Francis Group), Boca Raton, pp 35–66

    Google Scholar 

  • Seppo L, Jauhiainen T, Poussa T, Korpela R (2003) A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects. Am J Clin Nutr 77:326–330

    CAS  Google Scholar 

  • Sgouras D, Maragkoudakis P, Petraki K, Martinez-Gonzalez B, Eriotou E, Michopoulos S, Kalantzopoulos G, Tsakalidou E, Mentis A (2004) In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus casei strain Shirota. Appl Environ Microbiol 70:518–526

    Article  CAS  Google Scholar 

  • Shida K, Takahashi R, Iwadate E, Takamizawa K, Yasui H, Sato T, Habu S, Hachimura S, Kaminogawa S (2002) Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin Exp Allergy 32:563–570

    Article  CAS  Google Scholar 

  • Søndergaard B, Olsson J, Ohlson K, Svensson U, Bytzer P, Ekesbo R (2011) Effects of probiotic fermented milk on symptoms and intestinal flora in patients with irritable bowel syndrome: a randomised, placebo-controlled trial. Scand J Gastroenterol 46:663–672

    Article  Google Scholar 

  • Sun J, Hu XL, Le GW, Shi YH (2010) Lactobacilli prevent hydroxy radical production and inhibit Escherichia coli and Enterococcus growth in system mimicking colon fermentation. Lett Appl Microbiol 50:264–269

    Article  CAS  Google Scholar 

  • Takano T (2002) Anti-hypertensive activity of fermented dairy products containing biogenic peptides. Antonie Van Leeuwenhoek 82:333–340

    Article  CAS  Google Scholar 

  • Takemura N, Okubo T, Sonoyama K (2010) Lactobacillus plantarum strain No. 14 reduces adipocyte size in mice fed high-fat diet. Exp Biol Med (Maywood) 235:849–856

    Article  CAS  Google Scholar 

  • Tobita K, Yanaka H, Otani H (2010a) Anti-allergic effects of Lactobacillus crispatus KT-11 strain on ovalbumin-sensitised BALB/c mice. Anim Sci J 81:699–705

    Article  Google Scholar 

  • Tobita K, Yanaka H, Otani H (2010b) The antiallergic effects and acute toxicity of Lactobacillus crispatus KT-11 cultured in food grade medium. J Agric Food Chem 58:6498–6502

    Article  CAS  Google Scholar 

  • Tsai YT, Cheng PC, Fan CK, Pan TM (2008) Time-dependent persistence of enhanced immune response by a potential probiotic strain Lactobacillus paracasei subsp. paracasei NTU 101. Int J Food Microbiol 128:219–225

    Article  CAS  Google Scholar 

  • Tsai TY, Chu LH, Lee CL, Pan TM (2009) Atherosclerosis preventing activity of lactic acid bacteria-fermented milk–soymilk supplemented with Momordica charantia. J Agric Food Chem 57:2065–2071

    Article  CAS  Google Scholar 

  • Tsai YT, Cheng PC, Liao JW, Pan TM (2010a) Effect of the administration of Lactobacillus paracasei subsp. paracasei NTU 101 on Peyer’s patch-mediated mucosal immunity. Int Immunopharmacol 10:791–798

    Article  CAS  Google Scholar 

  • Tsai YT, Cheng PC, Pan TM (2010b) Immunomodulating activity of Lactobacillus paracasei subsp. paracasei NTU 101 in enterohemorrhagic Escherichia coli O157:H7-infected mice. J Agric Food Chem 58:11265–11272

    Article  CAS  Google Scholar 

  • Uchida M, Kurakazu K (2004) Yogurt containing Lactobacillus gasseri OLL2716 exerts gastroprotective action against acute gastric lesion and antral ulcer in rats. J Pharmacol Sci 96:84–90

    Article  CAS  Google Scholar 

  • USDA (2011) Dairy products annual summary. National Agricultural Statistics Service (NASS), USDA, Office of the Assistant Secretary for Civil Rights, Washington, DC, pp 9–51

    Google Scholar 

  • WHO (2011) The top 10 causes of death; Fact sheet N°310. WHO, Geneva. http://www.who.int/mediacentre/factsheets/fs310/en/index.html. Accessed 26 August 2011.

  • Xie N, Cui Y, Yin YN, Zhao X, Yang JW, Wang ZG, Fu N, Tang Y, Wang XH, Liu XW, Wang CL, Lu FG (2011) Effects of two Lactobacillus strains on lipid metabolism and intestinal microflora in rats fed a high-cholesterol diet. BMC Complement Altern Med 11:53–63

    Article  CAS  Google Scholar 

  • Yamamoto N, Maeno M, Takano T (1999) Purification and characterization of an antihypertensive peptide from a yogurt-like product fermented by Lactobacillus helveticus CPN4. J Dairy Sci 82:1388–1393

    Article  CAS  Google Scholar 

  • Yeo SK, Liong MT (2010) Angiotensin I-converting enzyme inhibitory activity and bioconversion of isoflavones by probiotics in soymilk supplemented with prebiotics. Int J Food Sci Nutr 61:161–181

    Article  CAS  Google Scholar 

  • Yoshida A, Aoki R, Kimoto-Nira H, Kobayashi M, Kawasumi T, Mizumachi K, Suzuki C (2011) Oral administration of live Lactococcus lactis C59 suppresses IgE antibody production in ovalbumin-sensitised mice via the regulation of interleukin-4 production. FEMS Immunol Med Microbiol 61:315–322

    Article  CAS  Google Scholar 

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Chiang, SS., Pan, TM. Beneficial effects of Lactobacillus paracasei subsp. paracasei NTU 101 and its fermented products. Appl Microbiol Biotechnol 93, 903–916 (2012). https://doi.org/10.1007/s00253-011-3753-x

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