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Applied Microbiology and Biotechnology

, Volume 90, Issue 3, pp 799–808 | Cite as

Peptide-based treatment of sepsis

  • Klaus BrandenburgEmail author
  • Jörg Andrä
  • Patrick Garidel
  • Thomas Gutsmann
Mini-Review

Abstract

Sepsis (blood poisoning) is a severe infectious disease with high mortality, and no effective therapy is actually known. In the case of Gram-negative bacteria, endotoxins (lipopolysaccharides) are known to be responsible for the strong inflammation reaction leading to the systemic infection. Peptides based on endotoxin-binding domains of human or animal proteins represent a promising approach in sepsis research. Although so far no medicament is available, the progress in recent years might lead to a breakthrough in this field. In this review, recent investigations are summarised, which may lead to an understanding of the mechanisms of action of peptides to suppress the inflammation reaction in vitro and in vivo (animal models) and thus may allow the development of effective anti-septic drugs.

Keywords

Sepsis Endotoxin Lipopolysaccharide Antimicrobial peptides Defensins Limulus 

Notes

Acknowledgements

The authors are indebted the German ministry BMBF for financial support (K.B. 01GU0824). J.A. acknowledges the financial support from the German Science Foundation (DFG) grant AN301/5-1.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Klaus Brandenburg
    • 1
    • 3
    Email author
  • Jörg Andrä
    • 1
  • Patrick Garidel
    • 2
  • Thomas Gutsmann
    • 1
  1. 1.Forschungszentrum Borstel, Leibniz-Zentrum für Medizin and BiowissenschaftenBorstelGermany
  2. 2.Martin-Luther-Universität Halle-Wittenberg, Institut für Physikalische Chemie, 06120 HalleGermany and University of KaiserslauternKaiserslauternGermany
  3. 3.Forschungszentrum Borstel, BiophysicsBorstelGermany

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