The promise of synthetic biology
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DNA synthesis has become one of the technological bases of a new concept in biology: synthetic biology. The vision of synthetic biology is a systematic, hierarchical design of artificial, biology-inspired systems using robust, standardized, and well-characterized building blocks. The design concept and examples from four fields of application (genetic circuits, protein design, platform technologies, and pathway engineering) are discussed, which demonstrate the usefulness and the promises of synthetic biology. The vision of synthetic biology is to develop complex systems by simplified solutions using available material and knowledge. Synthetic biology also opens a door toward new biomaterials that do not occur in nature.
KeywordsModular design Genetic circuits Protein design DNA synthesis
Inspiration and financial support from the EU-NEST program on synthetic biology (EUROBIOSYN) are greatly acknowledged. I am especially grateful for the fruitful discussions with Homme W. Hellinga and Sven Panke and for the constructive criticism by the unknown reviewers.
- Astier Y, Bayley H, Howorka S (2005) Protein components for nanodevices. Curr Opin Chem Biol 9:576–584Google Scholar
- Gilmore MA, Steward LE, Chamberlin AR (1999) Incorporation of noncoded amino acids by in vitro protein biosynthesis. In: Schmidtchen FP (ed) Implementation and redesign of catalytic function in biopolymers. Springer, BerlinGoogle Scholar
- Menzella HG, Reisinger SJ, Welch M, Kealey JT, Kennedy J, Reid R, Tran CQ, Santi DV (2006) Redesign, synthesis and functional expression of the 6-deoxyerythronolide B polyketide synthase gene cluster. J Ind Microbiol Biotechnol 33:22–28Google Scholar
- Raab RM, Tyo K, Stephanopoulos G (2005) Metabolic engineering. Adv Biochem Eng Biotechnol 100:1–17Google Scholar
- Scott P (2003) The wrong stuff?: attempts at flight before (& after) the Wright brothers. Hylas Publishing, New YorkGoogle Scholar
- Svendsen A (2004) Enzyme functionality: design, engineering, and screening. CRC, Boca Raton, FLGoogle Scholar
- Wang L, Brock A, Herberich B, Schultz PG (2001) Expanding the genetic code of Escherichia coli. Science 292:498–500Google Scholar