Applied Microbiology and Biotechnology

, Volume 72, Issue 6, pp 1152–1156 | Cite as

Hypoglycemic activity of the fungi Cordyceps militaris, Cordyceps sinensis, Tricholoma mongolicum, and Omphalia lapidescens in streptozotocin-induced diabetic rats

  • Guoqing Zhang
  • Yuedong Huang
  • Yong Bian
  • Jack H. Wong
  • T. B. Ng
  • Hexiang Wang
Biotechnological Products and Process Engineering

Abstract

Crude extracts were prepared from fruiting bodies and mycelia of the medicinal fungus Cordyceps militaris, and a polysaccharide-enriched fraction was obtained after extraction with hot water and ethanol precipitation. Polysaccharide-enriched fractions were similarly prepared from Cordyceps sinensis, Omphalia lapidescens, and Tricholoma mongolicum. The various aforementioned preparations were orally administered into different groups of adult rats 24 h before an intraperitoneal injection of streptozotocin (40 mg/kg body weight), and subsequently daily for another 4 days. The dosage used was 10 mg/kg body weight for polysaccharide-enriched preparations and 100 mg/kg body weight for crude extracts. Control rats received distilled water instead of crude extract or polysaccharide-enriched preparation. It was found in the control rats that plasma glucose level rose from about 90 mg/dl before streptozotocin injection to levels that were maintained at about 300 mg/dl postinjection. All preparations produced hypoglycemic effects. C. militaris polysaccharide-enriched fraction displayed a more prominent effect than that of C. sinensis polysaccharide-enriched fraction which in turn was more potent than that of O. lapidescens and T. mongolicum polysaccharide-enriched fractions. The hypoglycemic effect of C. militaris polysaccharide-enriched fraction was dose-dependent.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Guoqing Zhang
    • 1
  • Yuedong Huang
    • 1
  • Yong Bian
    • 1
  • Jack H. Wong
    • 2
  • T. B. Ng
    • 2
  • Hexiang Wang
    • 1
  1. 1.State Key Laboratory for Agrobiotechnology and Department of MicrobiologyChina Agricultural UniversityBeijing 100094People’s Republic of China
  2. 2.Department of Biochemistry, Faculty of MedicineThe Chinese University of Hong KongShatinPeople’s Republic of China

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