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Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken

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Abstract

Monacolin K is a secondary metabolite produced by Monascus species. It was found that it is able to decrease cholesterol levels. In this study, red mold rice (RMR) was added to the diet of Arbor Acres broiler chickens, and the cholesterol level in meat, as well as the concentration of triglyceride, the high-density lipoprotein cholesterol (HDL-C), and the low-density lipoprotein cholesterol (LDL-C) in the serum were evaluated. Four-week-old broilers are studied and divided into four groups in that each group contains 15 subjects. A 3-week experimental feeding trial was conducted in which three groups of broilers were fed 2.0, 5.0, and 8.0% of RMR (RMR groups) within their diet, respectively, and the result was compared to the control group. The results indicated that for each RMR group, the cholesterol content was significantly lower than that of the control group; in addition, their meat products contain higher level of unsaturated fatty acids. Triglyceride and cholesterol concentration in serum was also found to be considerably lower in RMR groups when compared to control group. Finally, in RMR groups, HDL-C/LDL-C and HDL-C/cholesterol ratios were all higher than those of the control group. In short, the results demonstrated that the cholesterol levels could be lowered by adding RMR to the diet of chickens.

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References

  • Aletor VA, Eder K, Becker K, Paulicks BR, Roth FX, Roth-Maier DA (2003) The effect of conjugated linoleic acid or an α-glucosidase inhibitor on tissue lipid concentrations and fatty acid composition of broiler chicks fed a low-protein diet. Poult Sci 82:796–804

    Article  CAS  Google Scholar 

  • Aniya Y, Ohtani II, Higa T, Miyagi C, Gibo H, Shimabukuro M, Nakanish H, Taira J (2000) Dimerumic acid as an antioxidant of the mold: Monascus anka. Free Radic Boil Med 28:999–1004

    Article  CAS  Google Scholar 

  • Ashgar A, Lin CF, Gray JI, Buckley DJ, Booren AM, Crackei R, Flegai CJ (1989) Influence of oxidized dietary oil and antioxidant supplementation on membrane bound lipid stability in broiler meat. Br Poult Sci 30:815–823

    Article  Google Scholar 

  • Aviram M, Dankner G, Cogan U, Hochgraf E, Brook JG (1992) Lovastatin inhibitors low-density lipoprotein oxidation and alters its fluidity and uptake by macrophages: in vitro and in vivo studies. Metabolism 41:229–235

    Article  CAS  Google Scholar 

  • Ayerza R, Coates W, Lauria M (2002) Chia seed (Salvia hispanica L.) as an [omega]-3 fatty acid source for broilers: influence on fatty acid composition, cholesterol and fat content of white and dark meats, growth performance and sensory characteristics. Poult Sci 81:826–837

    Article  CAS  Google Scholar 

  • Bartov I, Bornstein S (1997) Stability of abdominal fat and meat of broilers: the interrelationship between the effects of dietary fat and vitamin E supplements. Br Poult Sci 18:59–68

    Article  Google Scholar 

  • Benamira M, Johnson K, Chaudary A, Bruner K, Tibbetts C, Marnett LJ (1995) Induction of mutations by replication of malondialdehyde-modified M13 DNA in Escheria coli: determination of the extent of DNA modification, genetic requirements for mutagenesis and type of mutation induced. Carcinogenesis 16:93–99

    Article  CAS  Google Scholar 

  • Boyd NF, McGuire V (1991) The possible role of lipid peroxidation in breast cancer risk. Free Radic Biol Med 10:185–190

    Article  CAS  Google Scholar 

  • Endo A (1979) Monacolin K, a new hypocholesterolemic agent produced by Monascus species. J Antibiot 32:852–854

    Article  CAS  Google Scholar 

  • Grau A, Guardiola F, Grimpa S, Barroeta AC, Codony R (2001) Oxidative stability dark chicken meat through frozen storage: influence of dietary fat and α-tocopherol and ascorbic acid supplementation. Poult Sci 80:1630–1642

    Article  CAS  Google Scholar 

  • Harmon AW, Harp JB (2001) Differential effects of flavonoids on 3T3-L1 adipogenesis and lipolysis. Am J Physiol Cell Physiol 280:807–813

    Article  Google Scholar 

  • Jeon T, Hwang SG, Hirai S, Matsui T, Yano H, Kawada T, Lim BO, Park DK (2004) Red yeast rice extracts suppress adipogenesis by down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells. Life Sci 75:3195–3203

    Article  CAS  Google Scholar 

  • Juzlova P, Rezanka T, Martinkova L, Kren V (1996) Long-chain fatty acids from Monascus purpureus. Phytochemistry 43:151–153

    Article  CAS  Google Scholar 

  • Konjufca VH, Pesti GM, Bakalli RI (1997) Modulation of cholesterol levels in broilers meat by dietary garlic and copper. Poult Sci 76:1264–1271

    Article  CAS  Google Scholar 

  • Kono I, Himeno K (2000) Changes in γ-aminobutyric acid content during beni-koji making. Biosci Biotechnol Biochem 64:617–619

    Article  CAS  Google Scholar 

  • Lin JH, Lin YH, Kuo CC (2002) Effect of dietary fish oil fatty acid composition, lipid oxidation and sensory property of chicken frankfurters during storage. Meat Sci 60:161–167

    Article  CAS  Google Scholar 

  • Lopez-Bote CJ, Grar JI, Gomaa EA, Flegal CJ (1998) Effect of dietary oat administration on lipid stability in broiler meat. Br Poult Sci 39:57–61

    Article  CAS  Google Scholar 

  • Manzoni M, Bergomi S, Rollini M, Cavazzoni V (1999) Production of statins by filamentous fungi. Biotechnol Lett 21:253–257

    Article  CAS  Google Scholar 

  • Martinkova L, Juzlova P, Kren V, Kucerouva Z, Havlicek V, Olsovsky P, Hovorka O, Rihova B, Vesly D, Vesela D, Ulrichova J, Prikrylova V (1999) Biological activities of oligoketide pigments of Monascus purpureus. Food Addit Contam 16:15–24

    Article  CAS  Google Scholar 

  • Mori AV, Mendonca CXJ, Santos CO (1999) Effect of dietary lipid-lowering drugs upon plasma lipids and egg yolk cholesterol levels of laying hens. J Agric Food Chem 47:4731–4735

    Article  CAS  Google Scholar 

  • Naber EC (1990) Cholesterol content of egg: can and should the industry try to change it? Feedstuffs 62:46–52

    Google Scholar 

  • O’Neill LM, Galvin K, Morrissey PA, Buckley DJ (1999) Effect of carnosine, salt and dietary vitamin E on the oxidative stability of chicken meat. Meat Sci 52:89–94

    Article  Google Scholar 

  • Pekkanen AN, Punsar S, Karvonen MJ (1992) Short and long term association of serum cholesterol with mortality. Am J Epidemiol 135:1252–1258

    Article  Google Scholar 

  • Pitman WA, Osgood DP, Smith D, Schaefer EJ, Ordovas JM (1998) The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL-C receptor and HMG-CoA reductase in F1B hamsters. Atherosclerosis 138:43–52

    Article  CAS  Google Scholar 

  • Ponte PI, Mendes I, Quaresma M, Aquia MN, Lemos JP, Ferreira LM, Soares MA, Alfaia CM, Prates JA, Fontes CM (2004) Cholesterol levels and sensory characteristics of meat from broilers consuming moderate to high levels of alfalfa. Poult Sci 83:810–814

    Article  CAS  Google Scholar 

  • Rule DC (1997) Direct transesterification of total fatty acids of adipose tissue, and of freeze–dried muscle and liver with boron-trifluoride in methanol. Meat Sci 46:23–32

    Article  CAS  Google Scholar 

  • Salih AM, Smith DM, Price JF, Dawson LE (1987) Modified extraction 2-thiobarbituric acid method for measuring lipid oxidation in poultry. Poult Sci 66:1483–1488

    Article  CAS  Google Scholar 

  • Skrivan M, Skrivanova V, Marounek M, Tumova E, Wolf J (2000) Influence of dietary fat source and copper supplementation on broiler performance, fatty acid profile of meat and depot fat, and on cholesterol content in meat. Br Poult Sci 41:608–614

    Article  CAS  Google Scholar 

  • Su YC, Huang JH (1976) Studies on the production of anka-pigment. J Chin Agric Chem Soc 14:45–58

    CAS  Google Scholar 

  • Tobert JA, Bell GD, Birtwell J, James I, Kukovetz WR, Pryor JS, Buntinx A, Holmes IB, Chao YS, Bolognese JA (1982) Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methyl-glutary-coenzyme A reductase, in healthy volunteers. J Clin Invest 68:913–919

    Article  Google Scholar 

  • Wang JJ, Pan TM (2003) Effect of red mold rice supplements on serum and egg yolk cholesterol levels of laying hens. J Agric Food Chem 51:4824–4829

    Article  CAS  Google Scholar 

  • Wang UL, Houng JY, Chang HS, Chien HCR, Hsu WH (1998) Selection of drug-resistant mutants Monascus pilosus for enhanced monacolin K production. J Chin Agric Chem Soc 36:192–200

    CAS  Google Scholar 

  • Wong HC, Koehler PE (1981) Production and isolation of an antibiotic from Monascus purpureus and its relationship to pigment production. J Food Sci 46:589–592

    Article  CAS  Google Scholar 

  • Yasukawa K, Takahashi M, Natori S, Yamazaki M, Takeuchi M, Takido M (1994) Azaphilones inhibit tumor promotion by 12-o-tetradecanoyl-phorbol-13-acetate. Oncology 45:108–112

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Biotechnology, Tajen University, 20 Weishin Road, Yanpu Shiang, Ping Tung, 907, Taiwan, Republic of China

    Jyh-Jye Wang & Meng-Jyh Shieh

  2. Institute of Microbiology and Biochemistry, National Taiwan University, Taipei, Taiwan, Republic of China

    Tzu-Ming Pan

  3. Graduate Institute of Pharmaceutical Technology, Tajen University, Ping Yung, Taiwan, Republic of China

    Chun-Chen Hsu

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  1. Jyh-Jye Wang
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  2. Tzu-Ming Pan
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Correspondence to Jyh-Jye Wang.

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Wang, JJ., Pan, TM., Shieh, MJ. et al. Effect of red mold rice supplements on serum and meat cholesterol levels of broilers chicken. Appl Microbiol Biotechnol 71, 812–818 (2006). https://doi.org/10.1007/s00253-005-0222-4

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  • DOI: https://doi.org/10.1007/s00253-005-0222-4

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