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Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase

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Abstract

Fungal manganese peroxidase was found to convert the persistent chemical warfare agent adamsite (phenarsarzin chloride) in a cell-free reaction mixture containing sodium malonate, Mn2+ ions, and reduced glutathione. The organo-arsenical compound disappeared completely within 48 h accompanied by the formation of a more polar metabolite with a clearly modified UV spectrum. Thus, As(III) in the adamsite molecule was oxidized by manganese peroxidase to As(V) which added dioxygen and released chloride.

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Authors and Affiliations

  1. Office of Environmental Investigation and Research, Stadtwaldstrasse 45a, 35037 , Marburg, Germany

    R. Haas

  2. Yanka Kupala, Grodno State University, Ozheshko Ulica 22, 230023, Grodno, Republic of Belarus

    O. Tsivunchyk

  3. Department of Chemistry, Philipps University of Marburg, Hans-Meerwein-Str., 35037 , Marburg, Germany

    K. Steinbach

  4. Institute of Immunology, Philipps University of Marburg, Pilgrimstein 2, 35037 , Marburg, Germany

    O. Tsivunchyk & E. v. Löw

  5. JenaBios GmbH, Löbstedter Strasse 78, 07749 , Jena, Germany

    K. Scheibner

  6. Unit of Environmental Biotechnology, International Graduate School Zittau, Markt 23, 02763, Zittau, Germany

    M. Hofrichter

Authors
  1. R. Haas
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  2. O. Tsivunchyk
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  3. K. Steinbach
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  4. E. v. Löw
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  5. K. Scheibner
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  6. M. Hofrichter
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Correspondence to R. Haas.

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Haas, R., Tsivunchyk, O., Steinbach, K. et al. Conversion of adamsite (phenarsarzin chloride) by fungal manganese peroxidase. Appl Microbiol Biotechnol 63, 564–566 (2004). https://doi.org/10.1007/s00253-003-1453-x

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  • DOI: https://doi.org/10.1007/s00253-003-1453-x

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