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Bacterial heme biosynthesis and its biotechnological application

Applied Microbiology and Biotechnology volume 63, pages 115–127 (2003)Cite this article

Abstract

Proteins carrying a prosthetic heme group are vital parts of bacterial energy conserving and stress response systems. They also mediate complex enzymatic reactions and regulatory processes. Here, we review the multistep biosynthetic pathway of heme formation including the enzymes involved and reaction mechanisms. Potential biotechnological implications are discussed.

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Acknowledgements

Research in the authors' laboratory was supported by funds from the Deutsche Forschungsgemeinschaft und the Fonds der Chemischen Industrie.

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  1. Institute for Microbiology, Technical University of Braunschweig, Spielmannstrasse 7, 38106, Braunschweig, Germany

    N. Frankenberg, J. Moser & D. Jahn

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  1. N. Frankenberg
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  2. J. Moser
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  3. D. Jahn
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Correspondence to N. Frankenberg.

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Frankenberg, N., Moser, J. & Jahn, D. Bacterial heme biosynthesis and its biotechnological application. Appl Microbiol Biotechnol 63, 115–127 (2003). https://doi.org/10.1007/s00253-003-1432-2

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  • DOI: https://doi.org/10.1007/s00253-003-1432-2

Keywords

  • Porphyria
  • Tetrapyrrole
  • Heme Biosynthesis
  • Ferrochelatase
  • Porphobilinogen Deaminase