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Applied Microbiology and Biotechnology

, Volume 60, Issue 5, pp 515–522 | Cite as

Regulation of gene expression in industrial fungi: Trichoderma

  •  R. Mach
  •  S. Zeilinger
Mini-Review

Abstract.

The genus Trichoderma comprises a group of filamentous ascomycetes that are now widely used in industrial applications because of their ability to produce extracellular hydrolases in large amounts. In addition, strong inducible promoters together with high secretory capacity have made Trichoderma an attractive host for heterologous protein production. Several promoters of genes encoding hydrolytic enzymes have been investigated in detail regarding their cis-acting elements and trans-acting factors. Potent inducer molecules, for both xylanolytic and cellulolytic enzyme systems, have been identified and characterized. Furthermore, models for the recognition of the insoluble substrates cellulose and xylan have been developed based on a large set of experiments. This mini-review summarises the considerable amount of data accumulated over the past three decades.

Keywords

Cellulose Hydrolase Trichoderma Heterologous Protein Potent Inducer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 2003

Authors and Affiliations

  •  R. Mach
    • 1
  •  S. Zeilinger
    • 1
  1. 1.Institute of Biochemical Engineering, Microbial Biochemistry and Gene Technology Group, Getreidemarkt 9/166, 1060 Vienna, Austria

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