Abstract
Studying the genetic polymorphism of the major histocompatibility complex class II genes in cattle, we identified a sequence (KUH1) which resembles those encoding class II β chains. The gene was shown to be transcribed in peripheral blood leukocytes. Sequence comparisons, Southern blot, and phylogenetic analyses indicate that (1) KUH1 represents a distinct DQB locus, which we propose to designate BoLA-DQB5, (2) DQB5 constitutes an ancient DQB locus which diverged from a common ancestor gene prior to the duplication resulting in DQB1 and DQB2, (3) DQB5 is associated with haplotypes which contain DQA5 and a duplicated DQ region.
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Received: 26 January 1999 / Revised: 20 April 1999
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Gelhaus, A., Förster, B. & Horstmann, R. Evidence for an additional cattle DQB locus. Immunogenetics 49, 879–885 (1999). https://doi.org/10.1007/s002510050568
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DOI: https://doi.org/10.1007/s002510050568