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A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus

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Abstract

 A single contig spanning the entire mouse immunoglobulin kappa light chain (Igk) locus on chromosome 6 has been established using yeast and bacterial artificial chromosome clones. Detailed mapping of the Igk locus indicates that a member of the Igk-V2 gene family, located about 3.5 megabases upstream of the Igk-J-C complex, is the most distal functional Igk-V gene. Sequence analyses of Igk-V genes and anonymous DNA segments provide indications for internal duplications at the 5′ end of the Igk-V locus and identify the likely origin of Igk-V orphon gene clusters located elsewhere in the mouse genome.

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Authors and Affiliations

  1. Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany, , , , , , DE

    Ingo W. Schupp, Thomas Schlake & T. Boehm

  2. Adolf-Butenandt-Institut für Physiologische Chemie der Universität München, Schillerstraße 44, D-80366 München, Germany, , , , , , DE

    Thomas Kirschbaum & Hans G. Zachau

Authors
  1. Ingo W. Schupp
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  2. Thomas Schlake
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  3. Thomas Kirschbaum
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  4. Hans G. Zachau
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  5. T. Boehm
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Received: 17 July 1996 / Revised: 2 September 1996

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Schupp, I., Schlake, T., Kirschbaum, T. et al. A yeast artificial chromosome contig spanning the mouse immunoglobulin kappa light chain locus. Immunogenetics 45, 180–187 (1997). https://doi.org/10.1007/s002510050187

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  • DOI: https://doi.org/10.1007/s002510050187

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