S100A7/Ran-binding protein 9 coevolution in mammals

D’Amico, Fabio; Nadalin, Francesca; Libra, Massimo

doi:10.1007/s00251-020-01155-9

Original Article
Published: 10 February 2020

S100A7/Ran-binding protein 9 coevolution in mammals

Immunogenetics volume 72, pages 155–164 (2020)Cite this article

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Abstract

S100A7 has been suggested to interact with Ran-binding protein 9. Both proteins are nowadays considered key effectors in immune response. Functional interaction between proteins is ensured by coevolution. The mechanisms of vertebrate coevolution between S100A7 and RanBP9 remain unclear. Several approaches for studying coevolution have been developed. Protein coevolution was inferred by calculating the linear correlation coefficients between inter-protein distance matrices using Mirrortree. We found an overall moderate correlation value (R = 0.53, p < 1e-06). Moreover, owing to the high conservation of RanBP9 protein among vertebrates, we chose to utilize a recent version of Blocks in Sequences (BIS2) algorithm implemented in BIS2Analyzer webserver. A coevolution cluster was identified between the two proteins (p < 8.10e-05). In conclusion, our coevolutionary analysis suggests that amino acid variations may modulate S100A7/RanBP9 interaction with potential pathogenic effects. Such findings could guide further analysis to better elucidate the function of S100A7 and RanBP9 and to design drugs targeting for these molecules in diseases.

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Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy
Fabio D’Amico & Massimo Libra
Laboratoire de Biologie Computationnelle et Quantitative (LCQB) - UMR 7238, Sorbonne Université, Univ P6, CNRS, IBPS, Paris, France
Francesca Nadalin

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Fabio D’Amico
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Francesca Nadalin
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Massimo Libra
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Correspondence to Fabio D’Amico.

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D’Amico, F., Nadalin, F. & Libra, M. S100A7/Ran-binding protein 9 coevolution in mammals. Immunogenetics 72, 155–164 (2020). https://doi.org/10.1007/s00251-020-01155-9

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Received: 25 October 2019
Accepted: 13 January 2020
Published: 10 February 2020
Issue Date: April 2020
DOI: https://doi.org/10.1007/s00251-020-01155-9

Keywords

Coevolution
S100A7
RanBP9
Mammals

S100A7/Ran-binding protein 9 coevolution in mammals

Abstract