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AIDS in chimpanzees: the role of MHC genes

Immunogenetics volume 69, pages 499–509 (2017)Cite this article

Abstract

The ancestral progenitor of common chimpanzees and bonobos experienced a selective sweep that ravaged its major histocompatibility complex (MHC) class I repertoire. The causative agent was probably an ancestral retrovirus, highly related to the contemporary HIV-1 strain, which initiated the acquired immunodeficiency syndrome pandemic in the human population. As a direct result, MHC class I allotypes with the capability of targeting conserved retroviral elements were enriched in the ancestral progenitor. Even today, the impact can be traced back by studying the functional capacities of the contemporary MHC class I allotypes of common chimpanzees. Viruses, however, have developed several strategies to manipulate the cell-surface expression of MHC class I genes. Monitoring the presence and absence of the MHC class I allotypes on the cell surface is conducted, for instance, by the hosts’ gene products of the killer cell immunoglobulin-like receptor (KIR) complex. Hence, one may wonder whether—in the future—any clues with regard to the signature of the MHC class I selective sweep might be unearthed for the KIR genes as well.

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Acknowledgements

We thank D. Devine for editing the manuscript and F. van Hassel for preparing the figures.

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Authors and Affiliations

  1. Comparative Genetics and Refinement, Biomedical Primate Research Centre, 2288 GJ, Rijswijk, The Netherlands

    Natasja G. de Groot, Corinne M. C. Heijmans & Ronald E. Bontrop

  2. Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH, Utrecht, The Netherlands

    Ronald E. Bontrop

Authors
  1. Natasja G. de Groot
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  2. Corinne M. C. Heijmans
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  3. Ronald E. Bontrop
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Correspondence to Natasja G. de Groot.

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This article is published in the Special Issue MHC Genes and Their Ligands in Health and Disease with Editor Prof. Ronald Bontrop.

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de Groot, N.G., Heijmans, C.M.C. & Bontrop, R.E. AIDS in chimpanzees: the role of MHC genes. Immunogenetics 69, 499–509 (2017). https://doi.org/10.1007/s00251-017-1006-6

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  • DOI: https://doi.org/10.1007/s00251-017-1006-6

Keywords

  • Chimpanzees
  • Selective sweep
  • Selection
  • Repertoire reduction