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Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques

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Abstract

Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-α, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.

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Acknowledgement

This research was supported by National Institutes of Health grants P51 RR000167 and R24 RR016038.

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Authors and Affiliations

  1. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI, 53715, USA

    Andrea Weiler, Gemma E. May, Nancy Wilson & David I. Watkins

  2. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, 53715, USA

    Andrea Weiler, Gemma E. May, Nancy Wilson & David I. Watkins

  3. Laboratory of Genomic Diversity, SAIC-Frederick, Incorporated, NCI-Frederick, Frederick, MD, 21702, USA

    Ying Qi

Authors
  1. Andrea Weiler
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  2. Gemma E. May
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  3. Ying Qi
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  4. Nancy Wilson
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  5. David I. Watkins
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Corresponding author

Correspondence to Andrea Weiler.

Additional information

Nucleotide sequence data reported are available in the GenBank database under accession numbers DQ890030–DQ890063, DQ887987–DQ888038, DQ902356–DQ902543, and DQ913647–DQ913733.

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Weiler, A., May, G.E., Qi, Y. et al. Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques. Immunogenetics 58, 1003–1009 (2006). https://doi.org/10.1007/s00251-006-0166-6

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  • DOI: https://doi.org/10.1007/s00251-006-0166-6

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