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Distribution of HLA-B alleles in Mexican Amerindian populations

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Abstract

In the present study we analyzed by PCR-SSO technique the HLA-B gene frequencies in 281 healthy individuals from four Mexican Amerindian populations (66 Mayos, 90 Mazatecans, 72 Nahuas and 53 Teenek). The most frequent alleles in all studied populations were HLA-B35, HLA-B39, and HLA-B40; however, some differences were observed between populations. The HLA-B35 allele was the most frequent in three of the four populations studied (Mayos, Nahuas and Teenek), whereas in Mazatecans the most frequent allele was HLA-B39. HLA-B40 presented frequencies higher than 10% in all groups. On the other hand, only Mayos presented an HLA-B51 gene frequency higher than 10%. When comparisons were made, important differences between groups were observed. The Teenek group presented an increased frequency of HLA-B35 when compared to Mazatecans and the HLA-B52 allele was increased in Nahuas and Teenek when compared to Mayos. An increased frequency of HLA-B39 was observed in Mazatecans when compared to Nahuas, Mayos and Teenek. Also, an increased frequency of HLA-B51 was observed in Mayos when compared to Mazatecans and Nahuas. These data corroborate the restricted polymorphism of HLA-B alleles and the high frequency of HLA-B35, HLA-B39 and HLA-B40 alleles in autochthonous American populations. In spite of the restriction in this polymorphism, differences in frequencies of HLA-B alleles could be helpful in distinguishing each of these populations.

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Acknowledgements

This work was supported in part by grants from the Consejo Nacional de Ciencia y Tecnología. México D.F., México and from the Ministerio de Ciencia y Tecnología (grant BMC-2002–1299), Spain.

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Authors and Affiliations

  1. Physiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico

    Gilberto Vargas-Alarcón, Guadalupe Hernández-Pacheco, José Manuel Rodríguez-Pérez, Nonanzit Pérez-Hernández & Carlos Rangel

  2. Molecular Biology and Immunogenetics Laboratory, Infectious Diseases Unit, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico

    Joaquín Zuñiga

  3. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Cynthia Villarreal-Garza & Julio Granados

  4. Department of Immunology, Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain

    Jorge Martínez-Laso & Antonio Arnaiz-Villena

  5. Department of Physiology, Instituto Nacional de Cardiología Ignacio Chávez. Juan Badiano No. 1, 14080, Tlalpan, México DF

    Gilberto Vargas-Alarcón

Authors
  1. Gilberto Vargas-Alarcón
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  2. Guadalupe Hernández-Pacheco
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  3. Joaquín Zuñiga
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  4. José Manuel Rodríguez-Pérez
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  6. Carlos Rangel
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  7. Cynthia Villarreal-Garza
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  8. Jorge Martínez-Laso
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  9. Julio Granados
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  10. Antonio Arnaiz-Villena
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Correspondence to Gilberto Vargas-Alarcón.

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Vargas-Alarcón, G., Hernández-Pacheco, G., Zuñiga, J. et al. Distribution of HLA-B alleles in Mexican Amerindian populations. Immunogenetics 54, 756–760 (2003). https://doi.org/10.1007/s00251-002-0522-0

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  • DOI: https://doi.org/10.1007/s00251-002-0522-0

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