Abstract
Electrical impedance measurements of biological tissue have many potential applications and tetrapolar impedance measurement (TPIM) with four electrodes is traditionally used which eliminates high skin contact impedance. A linear array of four electrodes for TPIM on the horizontal plane of a cylindrical volume conductor of diameter D, where the length of the array is πD/2 with potential electrodes near the centre of the array, will give a high sensitivity near the surface which reduces rapidly with depth. A recently proposed six-electrode variation of TPIM uses an additional pair of potential electrodes on the opposite side of the volume conductor in the same horizontal plane around the circumference, with the expectation that the sensitivity of the deeper regions will thereby be enhanced. The present work carries out a finite element simulation (using COMSOL) and an experimental phantom study (saline phantom) to quantitatively evaluate the improvement obtained by this new method. The new configuration doubled the sensitivity at the central region, which was reasonably uniform over a wider zone, gradually increasing towards the potential electrodes on both sides. This would be useful for a range of biological studies of deep body organs such as lungs, stomach, and bladder. where the respective external body shapes may be approximated by an oval cylinder and where electrical impedance techniques have shown promise.
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Acknowledgements
This work was supported partly by the Grants from Directorate of Advisory, Extension and Research Services, BUET, Bangladesh. The authors would like to acknowledge the Department of Biomedical Physics and Technology, University of Dhaka, Bangladesh for providing the necessary facilities to carry out this research.
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Roy, S.K., Karal, M.A.S., Kadir, M.A. et al. A new six-electrode electrical impedance technique for probing deep organs in the human body. Eur Biophys J 48, 711–719 (2019). https://doi.org/10.1007/s00249-019-01396-x
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DOI: https://doi.org/10.1007/s00249-019-01396-x