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Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules

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Abstract

This paper describes a proposed biophysical mechanism of a novel diagnostic method for cancer detection developed recently by Vedruccio. The diagnostic method is based on frequency selective absorption of electromagnetic waves by malignant tumors. Cancer is connected with mitochondrial malfunction (the Warburg effect) suggesting disrupted physical mechanisms. In addition to decreased energy conversion and nonutilized energy efflux, mitochondrial malfunction is accompanied by other negative effects in the cell. Diminished proton space charge layer and the static electric field around the outer membrane result in a lowered ordering level of cellular water and increased damping of microtubule-based cellular elastoelectrical vibration states. These changes manifest themselves in a dip in the amplitude of the signal with the fundamental frequency of the nonlinear microwave oscillator—the core of the diagnostic device—when coupled to the investigated cancerous tissue via the near-field. The dip is not present in the case of healthy tissue.

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Notes

  1. Due to special spectral transformation, energy is channeled to the lowest frequency modes, which may be strongly excited, oscillate coherently, and generate coherent electromagnetic fields (Fröhlich 1973, 1980). Generated coherent electromagnetic fields may participate in directed transport of molecules and particles (Pokorný 2001; Pokorný et al. 2005a), cytoskeleton dynamic organization (Pokorný et al. 2005b), interaction between cells (Pokorný 2006), and information transfer.

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Acknowledgments

The research results presented in this paper were partly supported by grant nos. P102/10/P454, 102/08/H008, P102/11/0649, and 102/11/0649 of the Czech Science Foundation GA CR, and by the grant no. SGS10/179/OHK3/2T/13 of the Grant Agency of the Czech Technical University in Prague.

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Authors and Affiliations

  1. Institute of Photonics and Electronics, Academy of Sciences of the Czech Republic, Chaberská 57, 18251, Prague 8, Czech Republic

    Jiří Pokorný, Michal Cifra & Ondřej Kučera

  2. COMSUBIN, Research Office, Italian Navy, La Spezia, Italy

    Clarbruno Vedruccio

  3. Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic

    Ondřej Kučera

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  1. Jiří Pokorný
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  2. Clarbruno Vedruccio
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  3. Michal Cifra
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  4. Ondřej Kučera
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Correspondence to Jiří Pokorný.

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Pokorný, J., Vedruccio, C., Cifra, M. et al. Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules. Eur Biophys J 40, 747–759 (2011). https://doi.org/10.1007/s00249-011-0688-1

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