European Hedgehogs (Erinaceus europaeus L.) as a Reservoir of Dermatophytes in Poland

Table 4 In vitro antifungal susceptibilities of dermatophyte isolates obtained from hedgehogs

Antifungal agents		MIC (µg/ml)	Dermatophyte species
Antifungal agents		MIC (µg/ml)	Trichophyton erinacei	Trichophyton mentagrophytes		Trichophyton benhamiae	Microsporum canis	Nannizzia gypsea	Nannizzia nana	Paraphyton cookei	Nannizzia fulva*
Allylamine	NFT	MIC₅₀	0.016	0.008		0.004	0.032	0.25	0.032	0.25	0.032
		MIC₉₀	0.032	0.016		0.016	0.064	0.25	0.032	0.5
	TRB	MIC₅₀	0.004	0.008	(2)	0.008	0.016	0.0125	0.032	0.0125	0.032
		MIC₉₀	0.0016	2	(2)	0.032	0.016	0.25	0.064	0.032
Polyenes	AMB	MIC₅₀	0.25	0.25		0.125	0.25	0.064	0.125	0.25	0.5
		MIC₉₀	0.25	0.5		0.25	1	0.25	0.5	0.5
Non-polyenes	GRE	MIC₅₀	1	1		0.5	0.25	0.5	0.25	1	0.5
		MIC₉₀	1	2		1	1	0.5	1	2
Imidazoles	KTC	MIC₅₀	0.5	0.5		0.25	0.125	0.125	1	0.5	0.5
		MIC₉₀	0.5	2		0.5	0.5	0.125	1	1
	MCZ	MIC₅₀	0.032	0.064		0.016	0.032	0.064	0.5	0.125	0.064
		MIC₉₀	0.125	0.125		0.125	0.064	0.125	2	0.25
	ENC	MIC₅₀	0.125	0.25		0.064	0.032	0.5	0.5	0.25	0.032
		MIC₉₀	0.25	2		0.25	0.125	1	0.5	1
	LUC	MIC₅₀	0.004	0.004		0.016	0.008	0.016	0.008	0.016	0.008
		MIC₉₀	0.016	0.008		0.032	0.016	0.064	0.064	0.016
Triazoles	ITC	MIC₅₀	0.25	0.5		0.125	0.125	0.25	0.125	0.25	0.25
		MIC₉₀	1	2		0.25	1	0.5	1	1
	FLC	MIC₅₀	16	32		16	16	8	4	8	64
		MIC₉₀	32	64		64	16	16	16	32
	VRC	MIC₅₀	0.032	0.016		0.032	0.064	0.016	0.125	0.25	0.125
		MIC₉₀	0.125	0.064		0.25	0.125	0.064	0.5	1
Pyridinone derivatives	CPO	MIC₅₀	0.064	0.016		0.032	0.25	0.016	0.032	0.064	0.032
		MIC₉₀	0.064	0.032		0.064	0.5	0.064	0.032	0.064
Phenyl morpholine derivatives	AMR	MIC₅₀	0.008	0.016		0.008	0.016	0.032	0.008	0.016	0.016
		MIC₉₀	0.016	0.064		0.008	0.032	0.032	0.008	0.016

Notes: abbreviations of antifungal substances: AMB, amphotericin B; AMR, amorolfine; CPO, ciclopirox; ENC, enilconazole; FLC, fluconazole; GRE, griseofulvin; ITC, itraconazole; KTC, ketoconazole; LUC, luliconazole; MCZ, miconazole; NFT, naftifine; TRB, terbinafine; VRC, voriconazole; (n), number of strains that showed resistance to terbinafine (MIC = 2 µg/ml); ^STstatistically significantly the lowest result in human/animals group; *the result presented for the two obtained isolates