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Vaginal Microbiota: Age Dynamic and Ethnic Particularities of Algerian Women


The composition of the vaginal microbiota is a key element for maintaining gynecological and reproductive health. With the aim of obtaining an accurate overview of the vaginal microbiota of Algerian women, in terms of their age and ethnic group, we conducted a 16S rRNA gene targeted metagenomic analysis of 100 vaginal samples taken from healthy childbearing and menopausal women. These data were used to establish the pattern of the vaginal microbiota during reproductive and postreproductive phases. Hormone levels were correlated to changes in microbial composition for menopausal women. The ethnic comparison revealed a particular microbiota profile for Algerian women, with a dominance of CST III and CST I. A rapid qPCR method developed by the authors was successfully used to identify the vaginal bacterial pattern for a customized gynecological management.

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Liza Ouarabi received a PhD scholar fellowship from the Algerian-French governments through the PROFAS program. The authors thank Dr. Brahim Ouarabi for kindly providing samples used in this study. Similarly, the authors thank Dr. Rabia Ladjouzi for his assistance with the qPCR assessment. The authors are indebted to Dr. S. W. Elson for critical reading and English improvement of the manuscript.


The Région des Hauts-de-France provided the Alibiotech CPER/FEDER 2016-2021 grant, which was partly used here for the metagenomic analyses.

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Correspondence to Anca Lucau-Danila.

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The authors declare that there is no conflict of interest.

Electronic Supplementary Material

Online Resource 1.

List of subjects included in the study. Y - young women, M – menopausal women, BMI - body mass index. (XLSX 23 kb)

Online Resource 2.

List of bacterial species in the vaginal microbiota of Algerian young (Y) and menopausal (M) women (PDF 1253 kb)

Online Resource 3.

Oestradiol variations and microbiota composition (PDF 758 kb)

Online Resource 4.

Age dynamics of bacterial species in vaginal microbiota of young and menopausal women (PDF 151 kb)

Online Resource 5.

CST composition (%) of the vaginal microbiota in different ethnic groups around the world (PDF 294 kb)

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Ouarabi, L., Drider, D., Taminiau, B. et al. Vaginal Microbiota: Age Dynamic and Ethnic Particularities of Algerian Women. Microb Ecol 82, 1020–1029 (2021).

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  • Vaginal microbiota
  • Metagenetics
  • Menopause
  • Probiotics
  • Ethnicity