Abstract
A total of 44181 serum samples from 16733 pregnant women were analyzed for findings suggesting primary Toxoplasma infection. Thirty-seven newborns exposed to maternal primary Toxoplasma infection in utero were studied prospectively with ultrasound, CT, and MRI for signs of intrauterine infection. Their mothers had been treated during pregnancy, and all infants were treated. The children were assigned to three groups according to their mothers’ serological status, and the radiological results were compared with the clinical outcome. Although radiological signs were scarce, ultrasound findings combined with maternal serology were found to be significantly related to clinical outcome.
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Robinson RO, Baumann RJ (1980) Late cerebral relapse of congenital toxoplasmosis. Arch Dis Child 55: 231–232
Wilson CB, Remington JS, Stagno S (1980) Development of adverse sequelae in children born with subclinical toxoplasma infection. Pediatrics 66: 767–774
Diebler C, Dusser A, Dulac O (1985) Congenital toxoplasmosis: clinical and radiological findings of the cerebral lesions. Neuroradiology 27: 125–130
Eichenwald HF (1960) A study of congenital toxoplasmosis with particular emphasis on clinical manifestations, sequelae and therapy. In: Simm JC (ed) Human toxoplasmosis. Munksgaard, Copenhagen, pp 41–49
Collins AT, Cromwell LD (1980) Computed tomography in the evaluation of congenital cerebral toxoplasmosis. J Comput Assist Tomogr 4: 326–329
Lappalainen M, Koskela P, Hedman K, Teramo K, Ämmälä P, Hiilesmaa V, Koskiniemi M (1992) Incidence of primary toxoplasma infections during pregnancy in southern Finland: a prospective cohort study. Scand J Infect Dis 24: 97–104
Remington JS, Desmonts G (1990) Toxoplasmosis. In: Remington JS, Klein JO (eds) Infectious diseases of the fetus and newborn infant, 3rd edn. Saunders, Philadelphia, pp 98–195
Frank JL (1986) Sonography of intracranial infections in infants and children. Neuroradiology 28: 440–445
Tomá P, Mangano GM, Mezzano P, Lazzini F, Bonmacci W, Serra G (1989) Cerebral ultrasound images in prenatal cytomegalovirus infection. Neuroradiology 31: 278–279
Teele RL, Hernanz-Schulman M, Sotrel A (1988) Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiology 169: 423–427
Ben-Ami T, Yousefzadeh D, Backus M, Reichman B, Kessel A, Hammerman-Rozemberg C (1990) Lenticulostriate vasculopathy in infants with infections of central nervous system: sonographic and Doppler findings. Pediatr Radiol 20: 575–579
Lappalainen M, Koskela P, Koskiniemi M, Ammälä P, Hiilesmaa V, Teramo K, Raivio KO, Remington JS, Hedman K (1993) Toxoplasmosis acquired during pregnancy: improved serodiagnosis based on avidity of IgG. J Infect Dis 167: 691–697
Shackelford GD, Fuling KH, Glasier CM (1983) Cysts of the subependymal germinal matrix: sonography demonstration with pathologic correlation. Radiology 149: 117–121
Butt W, Mackay RJ, de Crespigny LC, Murton LJ, Roy RND (1984) Intracranial lesions of congenital cytomegalovirus infection detected by ultrasound scanning. Pediatrics 73: 611–614
Chitkara U, Cogswell C, Norton K, Wilkins I, Mehalek K, Berkowitz RL (1988) Choroid plexus cyst in the fetus: a benign anatomic variant or pathologic entity? Report of 41 cases and review of the literature. Obstet Gynecol 72: 185–189
Persutte WH, Lenke RR, Harris JH (1988) Antenatal sonographic identification of choroid plexus cysts: two case reports and literature review. J Diagn Med Sonography 4: 247–252
Ostlere SJ, Irving HC, Lilford RJ (1990) Fetal choroid plexus cysts: a report of 100 cases. Radiology 175: 753–755
Veyrac C, Couture A (1985) Normal and pathological choroid plexus ultrasound. Ann Radiol 28: 215–223
Gabrielli S, Reece EA, Pilu G, Perolo A, Rizzo N, Bovicelli L, Hobbins JC (1989) The clinical significance of prenatally diagnosed choroid plexus cysts. Am J Obstet Gynecol 160: 1207–1210
Blaakaer J (1986) Ultrasonic diagnosis of fetal ascites and toxoplasmosis. Acta Obstet Gynecol Scand 65: 653–654
Gotoff SP (1992) Infections of the newborn. In: Behrman RE, Kliegman RM, Nelson WE, Vaughan VC (eds) Nelson textbook of pediatrics, 14th edn. Saunders, Philadelphia, pp 495–524
Asanti R, Kunnas M, Palo T, Virkola K (1988) The large for date foetus: risk factors (in Finnish). Suomen Lääkäril 2: 16–20
Rosenberg HK, Markowitz RI, Kolberg H, Park C, Hubbard A, Bellah RD (1991) Normal splenic size in infants and children. Sonographic measurements. AJR 157: 119–121
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Virkola, K., Lappalainen, M., Valanne, L. et al. Radiological signs in newborns exposed to primary Toxoplasma infection in utero. Pediatr Radiol 27, 133–138 (1997). https://doi.org/10.1007/s002470050084
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DOI: https://doi.org/10.1007/s002470050084