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Assessment of lung ventilation of premature infants with bronchopulmonary dysplasia at 1.5 Tesla using phase-resolved functional lung magnetic resonance imaging

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Abstract

Background

The most common chronic complication of preterm birth is bronchopulmonary dysplasia (BPD), widely referred to as chronic lung disease of prematurity. All current definitions rely on characterizing the disease based on respiratory support level and do not provide full understanding of the underlying cardiopulmonary pathophysiology.

Objective

To evaluate a rapid functional lung imaging technique in premature infants and to quantitate pulmonary ventilation using 1.5 Tesla magnetic resonance imaging (MRI).

Materials and methods

We conducted a prospective MRI study of 12 premature infants in the neonatal intensive care unit (NICU) using the phase resolved functional lung MRI technique to calculate pulmonary ventilation parameters in preterm infants with and without BPD grade 0/1 (n = 6) and grade 2/3 (n = 6).

Results

The total ventilation defect percentage showed a significant difference between groups (16.0% IQR (11.0%,18%) BPD grade 2/3 vs. 8.0% IQR (4.5%,9.0%) BPD grade 0/1, p = 0.01).

Conclusion

Phase-resolved functional lung MRI is feasible for assessment of ventilation defect percentages in preterm infants and shows regional variation in localized lung function in this population.

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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to acknowledge the assistance of the pediatric and NICU nursing staff at NYP who were invaluable in the success of this study. Additional appreciation goes to the NYP MRI imaging staff and specifically to Edward Chung, B.S., R.T.(R) (MR)(ARRT), and Yasmin Abdallah, R.T.(R)(MR)(ARRT).

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Authors and Affiliations

  1. Citigroup Biomedical Imaging Center, Weill Cornell Medicine, 1300 York Avenue, Box 234, New York, NY, 10021, USA

    J. P. Dyke

  2. Department of Radiology, Weill Cornell Medicine, New York, NY, USA

    J. P. Dyke & A. Kovanlikaya

  3. Hannover Medical School, Hannover, Germany

    A. Voskrebenzev & J. Vogel-Claussen

  4. Biomedical Research in Endstage/Obstructive Lung Disease (BREATH), German Center for Lung Research (DZL), Hannover, Germany

    A. Voskrebenzev & J. Vogel-Claussen

  5. Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA

    L. K. Blatt, S. Worgall & J. M. Perlman

  6. Siemens Healthineers, Erlangen, Germany

    R. Grimm

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  1. J. P. Dyke
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  2. A. Voskrebenzev
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  3. L. K. Blatt
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  4. J. Vogel-Claussen
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  5. R. Grimm
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Corresponding author

Correspondence to J. P. Dyke.

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Conflicts of interest

R.G. is employed by Siemens Healthineers which manufactures the MRI scanner and some of the analysis software. All other authors declare no competing interests.

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Dyke, J.P., Voskrebenzev, A., Blatt, L.K. et al. Assessment of lung ventilation of premature infants with bronchopulmonary dysplasia at 1.5 Tesla using phase-resolved functional lung magnetic resonance imaging. Pediatr Radiol 53, 1076–1084 (2023). https://doi.org/10.1007/s00247-023-05598-6

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  • DOI: https://doi.org/10.1007/s00247-023-05598-6

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