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Comparison of ultrafast wave-controlled aliasing in parallel imaging (CAIPI) magnetization-prepared rapid acquisition gradient echo (MP-RAGE) and standard MP-RAGE in non-sedated children: initial clinical experience

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Abstract

Background

Fast magnetic resonance imaging (MRI) sequences are advantageous in pediatric imaging as they can lessen child discomfort, decrease motion artifact and improve scanner availability.

Objective

To evaluate the feasibility of an ultrafast wave-CAIPI (controlled aliasing in parallel imaging) MP-RAGE (magnetization-prepared rapid gradient echo) sequence for brain imaging of awake pediatric patients.

Materials and methods

Each MRI included a standard MP-RAGE sequence and an ultrafast wave-MP-RAGE sequence. Two neuroradiologists evaluated both sequences in terms of artifacts, noise, anatomical contrast and pathological contrast. A predefined 5-point scale was used by two independent pediatric neuroradiologists. A Wilcoxon signed-rank test was used to evaluate the difference between sequences for each variable.

Results

Twenty-four patients (14 males; mean age: 11.5±4.5 years, range: 1 month to 17.8 years) were included. Wave-CAIPI MP-RAGE provided a 77% reduction in scan time using a 32-channel coil and a 70% reduction using a 20-channel coil. Visualization of the pathology, artifacts and pathological enhancement (including parenchymal, leptomeningeal and dural enhancement) was not significantly different between standard MP-RAGE and wave-CAIPI MP-RAGE (all P>0.05). For central (P<0.001) and peripheral (P<0.001) noise, and the evaluation of the anatomical structures (P<0.001), the observers favored standard MP-RAGE over wave-CAIPI MP-RAGE.

Conclusion

Ultrafast brain imaging with wave-CAIPI MP-RAGE is feasible in awake pediatric patients, providing a substantial reduction in scan time at a cost of subjectively increased image noise.

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Acknowledgments

Authors Azadeh Tabari and John Conklin contributed equally.

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Authors and Affiliations

  1. Division of Pediatric Imaging, Department of Radiology, Massachusetts General Hospital, 55 Fruit St., Boston, MA, 02114, USA

    Azadeh Tabari, Maria Gabriela Figueiro Longo, Kawin Setsompop, Susie Yi Huang, Michael S. Gee & Paul J. Caruso

  2. Harvard Medical School, Boston, MA, USA

    Azadeh Tabari, John Conklin, Maria Gabriela Figueiro Longo, Camilo Jaimes, Stephen F. Cauley, John E. Kirsch, Susie Yi Huang, Otto Rapalino, Michael S. Gee & Paul J. Caruso

  3. Divisions of Emergency Imaging and Neuroradiology, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

    John Conklin, Otto Rapalino & Paul J. Caruso

  4. Department of Radiology, Boston Children’s Hospital, Boston, MA, USA

    Camilo Jaimes

  5. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA

    Kawin Setsompop, Stephen F. Cauley, John E. Kirsch & Susie Yi Huang

  6. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA

    Kawin Setsompop & Susie Yi Huang

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  1. Azadeh Tabari
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  2. John Conklin
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  3. Maria Gabriela Figueiro Longo
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  4. Camilo Jaimes
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  5. Kawin Setsompop
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  6. Stephen F. Cauley
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  7. John E. Kirsch
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  8. Susie Yi Huang
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  10. Michael S. Gee
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  11. Paul J. Caruso
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Correspondence to Azadeh Tabari.

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Tabari, A., Conklin, J., Figueiro Longo, M.G. et al. Comparison of ultrafast wave-controlled aliasing in parallel imaging (CAIPI) magnetization-prepared rapid acquisition gradient echo (MP-RAGE) and standard MP-RAGE in non-sedated children: initial clinical experience. Pediatr Radiol 51, 2009–2017 (2021). https://doi.org/10.1007/s00247-021-05117-5

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  • DOI: https://doi.org/10.1007/s00247-021-05117-5

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