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Cochlear signal alterations using pseudo-color perceptual enhancement for patients with sensorineural hearing loss

Pediatric Radiology volume 51, pages 1448–1456 (2021)Cite this article

Abstract

Background

Neuroimaging detection of sensorineural hearing loss (SNHL)-related temporal bone abnormalities is limited (20–50%). We hypothesize that cochlear signal differences in gray-scale data may exceed the threshold of human eye detection. Gray-scale images can be post-processed to enhance perception of tonal difference using “pseudo-color” schemes.

Objective

To compare patients with unilateral SNHL to age-matched normal magnetic resonance imaging (MRI) exams for “labyrinthine color differences” employing pseudo-color post-processing.

Materials and methods

The MRI database at an academic children’s hospital was queried for “hearing loss.” Only unilateral SNHL cases were analyzed. Sixty-nine imaging exams were reviewed. Thirteen age-matched normal MR exams in children without hearing loss were chosen for comparison. Pseudo-color was applied with post-processing assignment of specific hues to each gray-scale intensity value. Gray-scale and pseudo-color images were qualitatively evaluated for signal asymmetries by a board-certified neuroradiologist blinded to the side of SNHL.

Results

Twenty-six SNHL (mean: 7.6±3 years) and 13 normal control exams (mean: 7.3±4 years) were included. All patients had normal gray-scale cochlear signal and all controls had symmetrical pseudo-color signal. However, pseudo-color images revealed occult asymmetries localizing to the SNHL ear with lower values in 38%. Ninety-one percent of these cases showed concordance between the side of pseudo-color positivity and the side of hearing loss.

Conclusion

Pseudo-color perceptual image enhancement reveals intra-labyrinthine fluid alterations on MR exams in children with unilateral SNHL. Pseudo-color image enhancement techniques improve detection of cochlear pathology and could have therapeutic implications.

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References

  1. Billings KR, Kenna MA (1999) Causes of pediatric sensorineural hearing loss: yesterday and today. Arch Otolaryngol Head Neck Surg 125:517–521

    CAS  Article  Google Scholar 

  2. Davidson J, Hyde ML, Alberti PW (1989) Epidemiologic patterns in childhood hearing loss: a review. Int J Pediatr Otorhinolaryngol 17:239–266

    CAS  Article  Google Scholar 

  3. DeMarcantonio M, Choo DI (2015) Radiographic evaluation of children with hearing loss. Otolaryngol Clin N Am 48:913–932

    Article  Google Scholar 

  4. American Academy of Pediatrics, Joint Committee on Infant Hearing (2007) Year 2007 position statement: principles and guidelines for early hearing detection and intervention programs. Pediatrics 20:898–921

    Article  Google Scholar 

  5. Beck RL, Aschendorff A, Hassepaß F et al (2017) Cochlear implantation in children with congenital unilateral deafness: a case series. Otol Neurotol 38:e570–e576

    Article  Google Scholar 

  6. Hassepaß F, Aschendorff A, Wesarg T et al (2013) Unilateral deafness in children: audiologic and subjective assessment of hearing ability after cochlear implantation. Otol Neurotol 34:53–60

    Article  Google Scholar 

  7. Ross DS, Visser SN, Holstrum WJ et al (2010) Highly variable population-based prevalence rates of unilateral hearing loss after the application of common case definitions. Ear Hear 31:126–133

    Article  Google Scholar 

  8. Holstrum WJ, Gaffney M, Gravel JS et al (2008) Early intervention for children with unilateral and mild bilateral degrees of hearing loss. Trends Amplif 12:35–41

    Article  Google Scholar 

  9. Haffey T, Fowler N, Anne S (2013) Evaluation of unilateral sensorineural hearing loss in the pediatric patient. Int J Pediatr Otorhinolaryngol 77:955–958

  10. Anne S, Lieu JEC, Cohen MS (2017) Speech and language consequences of unilateral hearing loss: a systematic review. Otolaryngol Head Neck Surg 157:572–579

    Article  Google Scholar 

  11. Liming BJ, Carter J, Cheng A et al (2016) International pediatric otolaryngology group (IPOG) consensus recommendations: hearing loss in the pediatric patient. Int J Pediatr Otorhinolaryngol 90:251–258

    Article  Google Scholar 

  12. Huang BY, Zdanski C, Castillo M (2012) Pediatric sensorineural hearing loss, part 1: practical aspects for neuroradiologists. AJNR Am J Neuroradiol 33:211–217

    CAS  Article  Google Scholar 

  13. Huang BY, Zdanski C, Castillo M (2012) Pediatric sensorineural hearing loss, part 2: syndromic and acquired causes. AJNR Am J Neuroradiol 33:399–406

    CAS  Article  Google Scholar 

  14. Hasso AN, Drayer BP, Anderson RE et al (2000) Vertigo and hearing loss. American College of Radiology. ACR Appropriateness Criteria. Radiology 215 Suppl:471–478

  15. Gruber M, Brown C, Mahadevan M et al (2016) The yield of multigene testing in the management of pediatric unilateral sensorineural hearing loss. Otol Neurotol 37:1066–1070

    Article  Google Scholar 

  16. Preciado DA, Lim LHY, Cohen AP et al (2004) A diagnostic paradigm for childhood idiopathic sensorineural hearing loss. Otolaryngol Head Neck Surg 131:804–809

    Article  Google Scholar 

  17. Lowe LH, Vezina LG (1997) Sensorineural hearing loss in children. Radiographics 17:1079–1093

    CAS  Article  Google Scholar 

  18. Madden C, Halsted M, Benton C et al (2003) Enlarged vestibular aqueduct syndrome in the pediatric population. Otol Neurotol 24:625–632

    Article  Google Scholar 

  19. McClay JE, Booth TN, Parry DA et al (2008) Evaluation of pediatric sensorineural hearing loss with magnetic resonance imaging. Arch Otolaryngol Head Neck Surg 134:945–952

    Article  Google Scholar 

  20. Sheppard JJ, Stratton RH, Gazley C Jr (1969) Pseudocolor as a means of image enhancement. Am J Optom Arch Am Acad Optom 46:735–754

    Article  Google Scholar 

  21. Zabala-Travers S, Choi M, Cheng W-C, Badano A (2015) Effect of color visualization and display hardware on the visual assessment of pseudo-color medical images. Med Phys 42:2942–2954

    Article  Google Scholar 

  22. Liao W-H, Wu H-M, Wu H-Y et al (2016) Revisiting the relationship of three-dimensional fluid attenuation inversion recovery imaging and hearing outcomes in adults with idiopathic unilateral sudden sensorineural hearing loss. Eur J Radiol 85:2188–2194

    Article  Google Scholar 

  23. Naganawa S, Kawai H, Taoka T et al (2016) Heavily T2-weighted 3D-FLAIR improves the detection of cochlear lymph fluid signal abnormalities in patients with sudden sensorineural hearing loss. Magn Reson Med Sci 15:203–211

    Article  Google Scholar 

  24. Ryu IS, Yoon TH, Ahn JH et al (2011) Three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging in sudden sensorineural hearing loss: correlations with audiologic and vestibular testing. Otol Neurotol 32:1205–1209

    Article  Google Scholar 

  25. Marciniak R, Kociatkiewicz E, Jarnicki K (1993) Digitalized pseudo-color radiography of bones. Preliminary report on color significance in image processing. In: Pesch HJ, Stöß H, Kummer B (eds) Osteologie aktuell VII. Springer, Heidelberg, pp 555–556

    Chapter  Google Scholar 

  26. Kats L, Vered M (2014) Pseudo-color filter in two-dimensional imaging in dentistry. Refuat Hapeh Vehashinayim 31:13–15 59

    CAS  Google Scholar 

  27. Jakia A, Va’Juanna W, Umbaugh SE (2010) Frequency domain pseudo-color to enhance ultrasound images. Comput Inform Sci 3:24–35

    Google Scholar 

  28. Umbaugh SE (2005) Computer imaging: digital image analysis and processing. CRC Press, Boca Raton

    Google Scholar 

  29. Umbaugh SE (2010) Digital image processing and analysis: human and computer vision applications with CVIPtools. CRC Press, Boca Raton

    Book  Google Scholar 

  30. Tijahjadi T, Bowen DK (1989) The use of color in image enhancement of x-ray microtomographs. J Xray Sci Technol 1:171–189

    Google Scholar 

  31. Park MS, Byun JY, Yeo SG, Lee HY (2011) Use of pseudocolor for detecting otologic structures in CT. In: Homma N (ed) Theory and applications of CT imaging and analysis. Intech Europe, Rejeka, pp 205–212

    Google Scholar 

  32. Crowe EJ, Sharp PF, Undrill PE, Ross PG (1988) Effectiveness of colour in displaying radionuclide images. Med Biol Eng Comput 26:57–61

    CAS  Article  Google Scholar 

  33. Stapleton SJ, Caldwell CB, Leonhardt CL et al (1994) Determination of thresholds for detection of cerebellar blood flow deficits in SPECT images. J Nucl Med 35:1547–1555

    CAS  PubMed  Google Scholar 

  34. Pizer SM, Zimmerman JB (1983) Color display in ultrasonography. Ultrasound Med Biol 9:331–345

    CAS  Article  Google Scholar 

  35. Saba L, Argiolas GM, Raz E et al (2014) Carotid artery dissection on non-contrast CT: does color improve the diagnostic confidence? Eur J Radiol 83:2288–2293

    Article  Google Scholar 

  36. Goodall AF, Siddiq MA (2015) Current understanding of the pathogenesis of autoimmune inner ear disease: a review. Clin Otolaryngol 40:412–419

    CAS  Article  Google Scholar 

  37. Pizer SM, ter Haar Romeny BM (1991) Fundamental properties of medical image perception. J Digit Imaging 4:1–20

    CAS  Article  Google Scholar 

  38. Deeb SS (2005) The molecular basis of variation in human color vision. Clin Genet 67:369–377

    CAS  Article  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Children’s National Hospital, 111 Michigan Ave. NW, Washington, DC, 20010, USA

    Matthew T. Whitehead

  2. The George Washington University School of Medicine and Health Sciences, Washington, DC, USA

    Matthew T. Whitehead, Lori M. Guillot & Brian K. Reilly

  3. Department of Otolaryngology, Children’s National Hospital, Washington, DC, USA

    Lori M. Guillot & Brian K. Reilly

  4. Pediatric Ear, Nose and Throat of Atlanta, Atlanta, GA, USA

    Lori M. Guillot

Authors
  1. Matthew T. Whitehead
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  2. Lori M. Guillot
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  3. Brian K. Reilly
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Correspondence to Matthew T. Whitehead.

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Whitehead, M.T., Guillot, L.M. & Reilly, B.K. Cochlear signal alterations using pseudo-color perceptual enhancement for patients with sensorineural hearing loss. Pediatr Radiol 51, 1448–1456 (2021). https://doi.org/10.1007/s00247-021-04987-z

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  • DOI: https://doi.org/10.1007/s00247-021-04987-z

Keywords

  • Children
  • Magnetic resonance imaging
  • Perception
  • Pseudo-color
  • Sensorineural hearing loss