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Imaging features of pathologically proven pediatric splenic masses

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Abstract

Splenic masses present a diagnostic challenge to radiologists and clinicians alike, with a relative paucity of data correlating radiologic findings to pathological diagnosis in the pediatric population. To illustrate splenic mass imaging findings and approximate lesion prevalence, we retrospectively reviewed all splenectomies and splenic biopsies for splenic masses at a single academic pediatric hospital over a 10-year period in patients 18 years and younger. A total of 31 splenic masses were analyzed. Lesion prevalence, pathology and imaging features associated with sampled splenic masses are described. The lesions encountered include benign splenic cysts (9), vascular anomalies (7), hamartoma (3), leukemia/lymphoma (3), granulomata (3) and metastasis (2). We also identified single cases of angiosarcoma, splenic cord capillary hemangioma, congestive hemorrhage, and benign smooth muscle neoplasm.

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References

  1. Dachman AH, Ros PR, Murari PJ et al (1986) Nonparasitic splenic cysts: a report of 52 cases with radiologic-pathologic correlation. AJR Am J Roentgenol 147:537–542

    Article  CAS  Google Scholar 

  2. Urrutia M, Mergo PJ, Ros LH et al (1996) Cystic masses of the spleen: radiologic-pathologic correlation. Radiographics 16:107–129

    Article  CAS  Google Scholar 

  3. Lee HJ, Kim JW, Hong JH et al (2018) Cross-sectional imaging of splenic lesions: Radiographics fundamentals online presentation. Radiographics 38:435–436

    Article  Google Scholar 

  4. Abbott RM, Levy AD, Aguilera NS et al (2004) From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation. Radiographics 24:1137–1163

    Article  Google Scholar 

  5. Mulliken JB, Fishman SJ, Burrows PE (2000) Vascular anomalies. Curr Probl Surg 37:517–584

    Article  CAS  Google Scholar 

  6. Mulligan PR, Prajapati HJ, Martin LG, Patel TH (2014) Vascular anomalies: classification, imaging characteristics and implications for interventional radiology treatment approaches. Br J Radiol 87:20130392

    Article  CAS  Google Scholar 

  7. Alomari AI, Spencer SA, Arnold RW et al (2014) Fibro-adipose vascular anomaly: clinical-radiologic-pathologic features of a newly delineated disorder of the extremity. J Pediatr Orthop 34:109–117

    Article  Google Scholar 

  8. Paterson A, Frush DP, Donnelly LF et al (1999) A pattern-oriented approach to splenic imaging in infants and children. Radiographics 19:1465–1485

    Article  CAS  Google Scholar 

  9. Elsayes KM, Narra VR, Mukundan G et al (2005) MR imaging of the spleen: spectrum of abnormalities. Radiographics 25:967–982

    Article  Google Scholar 

  10. Chiu A, Czader M, Cheng L et al (2011) Clonal X-chromosome inactivation suggests that splenic cord capillary hemangioma is a true neoplasm and not a subtype of splenic hamartoma. Mod Pathol 24:108–116

    Article  CAS  Google Scholar 

  11. Bellah R, Suzuki-Bordalo L, Brecher E et al (2005) Desmoplastic small round cell tumor in the abdomen and pelvis: report of CT findings in 11 affected children and young adults. AJR Am J Roentgenol 184:1910–1914

    Article  Google Scholar 

  12. Pickhardt PJ, Fisher AJ, Balfe DM et al (1999) Desmoplastic small round cell tumor of the abdomen: radiologic-histopathologic correlation. Radiology 210:633–638

    Article  CAS  Google Scholar 

  13. Kaza RK, Azar S, Al-Hawary MM, Francis IR (2010) Primary and secondary neoplasms of the spleen. Cancer Imaging 10:173–182

    Article  CAS  Google Scholar 

  14. Balcar I, Seltzer SE, Davis S, Geller S (1984) CT patterns of splenic infarction: a clinical and experimental study. Radiology 151:723–729

    Article  CAS  Google Scholar 

  15. Maier W (1982) Computed tomography in the diagnosis of splenic infarction. Eur J Radiol 2:202–204

    CAS  PubMed  Google Scholar 

  16. Barbashina V, Heller DS, Hameed M et al (2000) Splenic smooth-muscle tumors in children with acquired immunodeficiency syndrome: report of two cases of this unusual location with evidence of an association with Epstein-Barr virus. Virchows Arch 436:138–139

    Article  CAS  Google Scholar 

  17. Le Bail B, Morel D, Merel P et al (1996) Cystic smooth-muscle tumor of the liver and spleen associated with Epstein-Barr virus after renal transplantation. Am J Surg Pathol 20:1418–1425

    Article  Google Scholar 

  18. Morel D, Merville P, Le Bail B et al (1996) Epstein-Barr virus (EBV)-associated hepatic and splenic smooth muscle tumours after kidney transplantation. Nephrol Dial Transplant 11:1864–1866

    Article  CAS  Google Scholar 

  19. Purgina B, Rao UN, Miettinen M, Pantanowitz L (2011) AIDS-related EBV-associated smooth muscle tumors: a review of 64 published cases. Pathol Res Int 2011:561548

    Google Scholar 

  20. Moore Dalal K, Antonescu CR, Dematteo RP, Maki RG (2008) EBV-associated smooth muscle neoplasms: solid tumors arising in the presence of immunosuppression and autoimmune diseases. Sarcoma 2008:859407

    Article  Google Scholar 

  21. Hussein K, Maecker-Kolhoff B, Donnerstag F et al (2013) Epstein-Barr virus-associated smooth muscle tumours after transplantation, infection with human immunodeficiency virus and congenital immunodeficiency syndromes. Pathobiology 80:297–301

    Article  Google Scholar 

  22. Levy AD, Abbott RM, Abbondanzo SL (2004) Littoral cell angioma of the spleen: CT features with clinicopathologic comparison. Radiology 230:485–490

    Article  Google Scholar 

  23. Oliver-Goldaracena JM, Blanco A, Miralles M, Martin-Gonzalez MA (1998) Littoral cell angioma of the spleen: US and MR imaging findings. Abdom Imaging 23:636–639

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, Boston Children’s Hospital, 300 Longwood Ave., Boston, MA, 02115, USA

    Mitchell W. Boehnke, Susan A. Connolly & Michael J. Callahan

  2. Department of Radiology and Imaging Sciences,, Emory University School of Medicine, Atlanta, GA, USA

    Christopher T. Watterson

  3. Department of Pathology, Boston Children’s Hospital, Boston, MA, USA

    Antonio R. Perez-Atayde

  4. Department of Surgery, Anesthesiology, Critical Care and Pain Medicine, Department of Pediatric Oncology, Boston Children’s Hospital, Boston, MA, USA

    Christopher B. Weldon

Authors
  1. Mitchell W. Boehnke
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  2. Christopher T. Watterson
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  3. Susan A. Connolly
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  4. Antonio R. Perez-Atayde
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  5. Christopher B. Weldon
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  6. Michael J. Callahan
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Correspondence to Mitchell W. Boehnke.

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Boehnke, M.W., Watterson, C.T., Connolly, S.A. et al. Imaging features of pathologically proven pediatric splenic masses. Pediatr Radiol 50, 1284–1292 (2020). https://doi.org/10.1007/s00247-020-04692-3

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  • DOI: https://doi.org/10.1007/s00247-020-04692-3

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