Another point of view on 2017 PRETEXT
Letter to the Editor
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We would like to congratulate Towbin et al. [ 1] for their nice paper on the revision of the radiologic staging system for the future Paediatric Hepatic International Tumour Trial. However, on behalf of the French Paediatric Liver Tumour Group (the French members of the International Childhood Liver Tumours Strategy Group), we would like to express our disagreement on a few points and therefore explain why we have decided to decline to be included among the authors.
Imaging recommendations: the authors recommend performing MRI with injection of a hepatocyte-specific contrast agent at diagnosis and at every time point, rather than CT. This recommendation, in a tumour that mainly develops in very young children (median age at diagnosis 1.4 years), deserves discussion [ 2].
The risk of a prolonged MRI examination under general anaesthesia, in an infant with a voluminous abdominal tumour, must be balanced with the risk of ionising radiation from a CT performed only with...
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Conflicts of interest
- 9.O’Neill AF, Towbin AJ, Krailo MD et al (2017) Characterization of pulmonary metastases in children with hepatoblastoma treated on Children’s Oncology Group protocol AHEP0731 (the treatment of children with all stages of hepatoblastoma): a report from the Children’s Oncology Group. J Clin Oncol 35:3465–3473CrossRefGoogle Scholar
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