Pediatric Radiology

, Volume 48, Issue 12, pp 1724–1735 | Cite as

Half-dose versus full-dose macrocyclic gadolinium at 3-T magnetic resonance imaging in paediatric bone and soft-tissue disease

  • Giovanna Stefania ColafatiEmail author
  • Enrica Rossi
  • Chiara Carducci
  • Simone Piga
  • Ioan Paul Voicu
  • Angela Mastronuzzi
  • Paolo Tomà
Original Article



Given the recent concerns about gadolinium-based contrast agent safety, dose reduction strategies are being investigated.


To compare half-dose and standard full-dose gadoterate meglumine at 3-tesla (T) MRI in paediatric bone and soft-tissue diseases.

Materials and methods

We prospectively enrolled 45 children (age range 2.7 months to 17.5 years, median age 8.7 years, 49 total anatomical segments) with bone and soft-tissue diseases (neoplastic, inflammatory/infectious, ischaemic and vascular) imaged at 3-T MRI. Two consecutive half-doses of gadoterate meglumine (0.05 mmol/kg body weight) were administered. Two sets of post-contrast T1-weighted images were obtained, one after the first half dose and the other after the second half dose. For qualitative analysis, three radiologists, masked to the gadolinium dose, compared the diagnostic quality of the images. For quantitative analysis, we compared signal-to-noise ratio and contrast-to-noise ratio at half and full doses.


Signal-to-noise ratio and contrast-to-noise ratio did not vary significantly between the two groups. Qualitative analysis yielded excellent image quality in both post-contrast image datasets (Cohen κ=0.8).


In paediatric bone and soft-tissue 3-T MRI, it is feasible to halve the standard dose of gadoterate meglumine without losing image quality.


3-T Children Contrast agent Contrast-to-noise ratio Dose Gadolinium Gadoterate meglumine Magnetic resonance imaging Signal-to-noise ratio 


Compliance with ethical standards

Conflicts of interest



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Imaging, Neuroradiology UnitBambino Gesù Children’s HospitalRomeItaly
  2. 2.Department of ImagingBambino Gesù Children’s HospitalRomeItaly
  3. 3.Unit of Clinical EpidemiologyBambino Gesù Children’s HospitalRomeItaly
  4. 4.Department of Hematology/Oncology and Stem Cell TransplantationBambino Gesù Children’s HospitalRomeItaly

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