Free-breathing quantification of hepatic fat in healthy children and children with nonalcoholic fatty liver disease using a multi-echo 3-D stack-of-radial MRI technique
In adults, noninvasive chemical shift encoded Cartesian magnetic resonance imaging (MRI) and single-voxel magnetic resonance (MR) spectroscopy (SVS) accurately quantify hepatic steatosis but require breath-holding. In children, especially young and sick children, breath-holding is often limited or not feasible. Sedation can facilitate breath-holding but is highly undesirable. For these reasons, there is a need to develop free-breathing MRI technology that accurately quantifies steatosis in all children.
This study aimed to compare non-sedated free-breathing multi-echo 3-D stack-of-radial (radial) MRI versus standard breath-holding MRI and SVS techniques in a group of children for fat quantification with respect to image quality, accuracy and repeatability.
Materials and methods
Healthy children (n=10, median age [±interquartile range]: 10.9 [±3.3] years) and overweight children with nonalcoholic fatty liver disease (NAFLD) (n=9, median age: 15.2 [±3.2] years) were imaged at 3 Tesla using free-breathing radial MRI, breath-holding Cartesian MRI and breath-holding SVS. Acquisitions were performed twice to assess repeatability (within-subject mean difference, MDwithin). Images and hepatic proton-density fat fraction (PDFF) maps were scored for image quality. Free-breathing and breath-holding PDFF were compared using linear regression (correlation coefficient, r and concordance correlation coefficient, ρc) and Bland-Altman analysis (mean difference). P<0.05 was considered significant.
In patients with NAFLD, free-breathing radial MRI demonstrated significantly less motion artifacts compared to breath-holding Cartesian (P<0.05). Free-breathing radial PDFF demonstrated a linear relationship (P<0.001) versus breath-holding SVS PDFF and breath-holding Cartesian PDFF with r=0.996 and ρc=0.994, and r=0.997 and ρc=0.995, respectively. The mean difference in PDFF between free-breathing radial MRI, breath-holding Cartesian MRI and breath-holding SVS was <0.7%. Repeated free-breathing radial MRI had MDwithin=0.25% for PDFF.
In this pediatric study, non-sedated free-breathing radial MRI provided accurate and repeatable hepatic PDFF measurements and improved image quality, compared to standard breath-holding MR techniques.
KeywordsChildren Fat Liver Magnetic resonance imaging Nonalcoholic fatty liver disease Quantification Radial multi-echo sequence
The authors thank Aaron Scheffler, Dr. Joanna Yeh, Barbara Lee, Tammy Floore, Glen Nyborg and Sergio Godinez at University of California Los Angeles (UCLA) for their help with this project. This work acknowledges the use of the International Society of Magnetic Resonance in Medicine Fat-Water Toolbox (http://ismrm.org/workshops/FatWater12/data.htm).
Research reported in this publication was supported in part by a UCLA Radiology Department Exploratory Research Grant.
Compliance with ethical standards
Conflicts of interest
T. Armstrong and H. H. Wu receive institutional research support from Siemens Healthineers.
- 1.Centers for Disease Control and Prevention. Overweight and Obesity. https://www.cdc.gov/obesity/data/childhood.html. Accessed 20 Nov 2017
- 23.Joshi M, Dillman JR, Singh K et al (2017) Quantitative MRI of fatty liver disease in a large pediatric cohort: correlation between liver fat fraction, stiffness, volume, and patient-specific factors. Abdom Radiol. https://doi.org/10.1007/s00261-017-1289-y
- 35.Fujinaga Y, Kitou Y, Ohya A et al (2016) Advantages of radial volumetric breath-hold examination (VIBE) with k-space weighted image contrast reconstruction (KWIC) over Cartesian VIBE in liver imaging of volunteers simulating inadequate or no breath-holding ability. Eur Radiol 26:2790–2797CrossRefPubMedGoogle Scholar
- 38.Armstrong T, Martin T, Stemmer A, et al (2017) Free-breathing fat quantification in the liver using a multiecho 3D stack-of-radial technique: investigation of motion compensation and quantification accuracy. Proc. Int. Soc. Magn. Reson. Med. 25th. p 363Google Scholar
- 43.International Society of Magnetic Resonance in Medicine (2012) ISMRM Fat Water Toolbox. https://www.ismrm.org/workshops/FatWater12/data.htm. Accessed 27 Feb 2012
- 44.Gleich DF (2009) Models and algorithms for pagerank sensitivity. Dissertation. Stanford UniversityGoogle Scholar
- 60.Fazeli Dehkordy S, Wolfson T, William Hong C et al (2017) Liver fat reduction following bariatric weight loss surgery is greater in the right lobe of the liver. Proc. Int. Soc. Magn. Reson. Med. 25th. p 123Google Scholar