Reversible lesions of the corpus callosum with initially restricted diffusion in a series of Caucasian children

  • Anthony Le Bras
  • Maia Proisy
  • Mathieu Kuchenbuch
  • Constantin Gomes
  • Catherine Tréguier
  • Sylvia Napuri
  • Emmanuel Quehen
  • Bertrand Bruneau
Original Article
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Abstract

Background

Reversible lesions of the corpus callosum with initial restricted diffusion on diffusion-weighted imaging (DWI) are rare and mainly described in the south Asiatic population.

Objective

The purpose of this study was to describe the clinical presentation, imaging findings, prognosis and etiology of transient restricted diffusion lesions of the corpus callosum in a series of Caucasian children.

Materials and methods

Seven children presenting with a transient restricted DWI lesion of the corpus callosum were included. Their clinical presentations and paraclinical examinations were investigated in addition to their MRI findings during the acute phase and at follow-up.

Results

Five patients initially presenting with prodromal flu-like symptoms were diagnosed with mild encephalopathy with reversible corpus callosum lesions, three of which were due to the influenza virus. For two patients (twins) with a stroke-like presentation and without febrile illness, a central nervous system manifestation of X-linked Charcot-Marie-Tooth disease with connexin 32 mutation was diagnosed. All patients had a good clinical prognosis without clinical sequelae or residual MRI lesion for all patients at follow-up.

Conclusion

A transient lesion of the corpus callosum with restricted diffusion should prompt the radiologist to suggest an infectious trigger in children. The prognosis of these patients was good with normalization of clinical symptoms and MRI without any specific treatment.

Keywords

Central nervous system infections Charcot-Marie-Tooth disease Children Corpus callosum Diffusion-weighted imaging Magnetic resonance imaging Reversible focal lesion 

Notes

Compliance with ethical standards

Conflicts of interest

None.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medical ImagingHôpital Sud, CHU de RennesRennesFrance
  2. 2.Department of Pediatric NeurologyHôpital sud, CHU RennesRennesFrance
  3. 3.Department of Medical ImagingCHU PontchaillouRennesFrance

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