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Imaging of the hip in juvenile idiopathic arthritis

  • Minisymposium: Juvenile Idiopathic Arthritis
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Abstract

Hip involvement is common and estimated to occur in approximately 35–63% of children with juvenile idiopathic arthritis (JIA). It is more prevalent in the aggressive systemic subtypes, with irreversible changes occurring as early as within 5 years of diagnosis. Whilst clinical parameters and joint examination can be useful for assessing disease severity, subclinical disease is known to exist and delayed treatment may herald a lifetime of disability and pain. Early recognition of JIA changes is therefore crucial in determining treatment options. Validated scoring systems in the radiologic assessment of the hip for clinical drug trials may inform treatment outcomes, although robust tools for analysis are still lacking. This review article details the modalities utilised for imaging the hip in children with JIA with particular efforts focused upon reliability and validity in their assessment of joint disease. We conclude with a short literature review on the potential future techniques being developed for hip joint imaging in JIA.

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References

  1. Ravelli A, Martini A (2007) Juvenile idiopathic arthritis. Lancet 369:767–778

    Article  PubMed  CAS  Google Scholar 

  2. Spencer CH, Bernstein GH (2002) Hip disease in juvenile rheumatoid arthritis. Curr Opin Rheumatol 14:536–541

    Article  PubMed  Google Scholar 

  3. Rostom S, Amine B, Bensabbah R et al (2008) Hip involvement in juvenile idiopathic arthritis. Clin Rheumatol 27:791–794

    Article  PubMed  CAS  Google Scholar 

  4. Hemke R, Nusman CM, van der Heijde DM et al (2015) Frequency of joint involvement in juvenile idiopathic arthritis during a 5 year follow-up of newly diagnosed patients: implications for MR imaging as outcome measure. Rheumatol Int 35:351–357

    Article  PubMed  Google Scholar 

  5. Russo RA, Katsicas MM (2013) Patients with very early-onset systemic juvenile idiopathic arthritis exhibit more inflammatory features and a worse outcome. J Rheumatol 40:329–334

    Article  PubMed  CAS  Google Scholar 

  6. Fantini F, Corradi A, Gerloni V et al (1997) The natural history of hip involvement in juvenile rheumatoid arthritis: a radiological and magnetic resonance imaging follow-up study. Rev Rhum Engl Ed 64:173S–178S

    PubMed  CAS  Google Scholar 

  7. Packham JC, Hall MA (2002) Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome. Rheumatology 41:1428–1435

    Article  PubMed  CAS  Google Scholar 

  8. Memari AH, Chamanara E, Ziaee V et al (2016) Behavioral problems in juvenile idiopathic arthritis: a controlled study to examine the risk of psychopathology in a chronic pediatric disorder. Int J Chronic Dis 2016:5726236

    PubMed  PubMed Central  Google Scholar 

  9. Fedrizzi MS, Ronchezel MV, Hilario MO et al (1997) Ultrasonography in the early diagnosis of hip joint involvement in juvenile rheumatoid arthritis. J Rheumatol 24:1820–1825

    PubMed  CAS  Google Scholar 

  10. Sheybani EF, Khanna G, White AJ, Demertzis JL (2013) Imaging of juvenile idiopathic arthritis: a mulitmodality approach. Radiographics 33:1253–1273

    Article  PubMed  Google Scholar 

  11. Ording Muller LS, Humphries P, Rosendahl K (2015) The joints in juvenile idiopathic arthritis. Insights Imaging 6:275–284

    Article  PubMed  PubMed Central  Google Scholar 

  12. Williams RA, Answll BM (1985) Radiological findings in seropositive juvenile chronic arthritis (juvenile rheumatoid arthritis) with particular reference to progression. Ann Rheum Dis 44:685–693

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. St Clair EW, van der Heijde DM, Smolen JS et al (2004) Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum 50:3432–3443

    Article  PubMed  CAS  Google Scholar 

  14. Bertamino M, Rossi F, Pistorio A et al (2010) Development and initial validation of a radiographic scoring system for the hip in juvenile idiopathic arthritis. J Rheumatol 37:432–439

    Article  PubMed  Google Scholar 

  15. Magni-Manzoni S, Epis O, Ravelli A et al (2009) Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis. Arthritis Rheum 61:1497–1504

    Article  PubMed  Google Scholar 

  16. Beggs I, Bianchi S, Bueno A et al (2016) Musculoskeletal ultrasound technical guidelines https://essr.org/content-essr/uploads/2016/10/hip.pdf. Accessed 19 June 2017

  17. Collado P, Vojinovic J, Nieto JC et al (2016) Toward standardized musculoskeletal ultrasound in pediatric rheumatology: normal age-related ultrasound findings. Arthritis Care Res 68:348–356

    Article  Google Scholar 

  18. Zuber Z, Owczarek A, Sobczyk M et al (2017) Establishing percentile charts for hip joint capsule and synovial cavity thickness in apparently helathy children. Pediatr Rheumatol 15:8

    Article  Google Scholar 

  19. Silva VB, Faquin G, Nicacio A et al (2013) Association between the ultrasonographic and clinical findings in the hips of patients with juvenile idiopathic arthritis. Rev Bras Reumatol 53:322–327

    Article  PubMed  Google Scholar 

  20. Bugni Miotto e Silva V, de Freitas Tavares da Silva C, de Aquiar Vilela Mitraud S et al (2014) Do patients with juvenile idiopathic arthritis in remission exhibit active synovitis on joint ultrasound? Rheumatol Int 34:937–945

    Article  PubMed  Google Scholar 

  21. Eich GF, Halle F, Hodler J et al (1994) Juvenile chronic arthritis: imaging of the knees and hips before and after intraarticular steroid injection. Pediatr Radiol 24:558–563

    Article  PubMed  CAS  Google Scholar 

  22. Laor T, Jaramillo D (2009) MR imaging insights into skeletal maturation: what is normal? Radiology 250:28–38

    Article  PubMed  Google Scholar 

  23. Jaramillo D, Villegas-Medina OL, Doty DK et al (2004) Age-related vascular changes in the epiphysis, physis, and metaphysis: normal findings on gadolinium-enhanced MRI of piglets. AJR Am J Roentgenol 182:353–360

    Article  PubMed  Google Scholar 

  24. Papavasiliou A, Siatras T, Bintoudi A et al (2014) The gymnasts’ hip and groin: a magnetic resonance imaging study in asymptomatic elite athletes. Skeletal Radiol 43:1071–1077

    Article  PubMed  CAS  Google Scholar 

  25. Nusman CM, Rosendahl K, Maas M (2016) MRI protocol for the assessment of juvenile idiopathic arthritis of the wrist: recommendations from the OMERACT MRI in JIA working group and health-e-child. J Rheumatol 43:1257–1258

    Article  PubMed  Google Scholar 

  26. Rieter JF, de Horatio LT, Nusman CM et al (2016) The many shades of enhancement: timing of post-gadolinium images strongly influences the scoring of juvenile idiopathic arthritis wrist involvement on MRI. Pediatr Radiol 46:1562–1567

    Article  PubMed  Google Scholar 

  27. Argyropoulou MI, Fanis SL, Xenakis T et al (2002) The role of MRI in the evaluation of hip joint disease in clinical subtypes of juvenile idiopathic arthritis. Br J Radiol 75:229–233

    Article  PubMed  CAS  Google Scholar 

  28. Nistala K, Babar J, Johnson K et al (2007) Clinical assessment and core outcome variables are poor predictors of hip arthritis diagnosed by MRI in juvenile idiopathic arthritis. Rheumatology 46:699–702

    Article  PubMed  CAS  Google Scholar 

  29. Kirkhus E, Flato B, Riise O et al (2011) Differences in MRI findings between subgroups of recent-onset childhood arthritis. Pediatr Radiol 41:432–440

    Article  PubMed  Google Scholar 

  30. El-Azeem MIA, Taha HA, El-Sherif AM (2012) Role of MRI in evaluation of hip joint involvement in juvenile idiopathic arthritis. The Egyptian Rheumatologist 34:75–82

    Article  Google Scholar 

  31. Madej T (2013) 3D imaging options and ultrasound contrast agents for the ultrasound assessment of pediatric rheumatic patients. J Ultrason 13:431–437

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kim HK, Shiraj S, Anton CG et al (2014) Age and sex dependency of cartilage T2 relaxation time mapping in MRI of children and adolescents. AJR Am J Roentgenol 202:626–632

    Article  PubMed  Google Scholar 

  33. Kight AC, Dardzinski BJ, Laor T, Graham TB (2004) Magnetic resonance imaging evaluation of the effects of juvenile rheumatoid arthritis on distal femoral weight-bearing cartilage. Arthritis Rheum 50:901–905

    Article  PubMed  Google Scholar 

  34. Kim HK, Laor T, Graham TB et al (2010) T2 relaxation time changes in distal femoral articular cartilage in children with juvenile idiopathic arthritis: a 3-year longitudinal study. AJR Am J Roentgenol 195:1021–1025

    Article  PubMed  Google Scholar 

  35. Jaimes C, Berman JI, Delgado J et al (2014) Diffusion-tensor imaging of the growing ends of long bones: pilot demonstration of columnar structure in the physes and metaphyses of the knee. Radiology 273:491–501

    Article  PubMed  Google Scholar 

  36. Ukai T, Sato M, Yamashita T et al (2015) Diffusion tensor imaging can detect the early stages of cartilage damage: a comparison study. BMC Musculoskelet Disord 16:35

    Article  PubMed  PubMed Central  Google Scholar 

  37. Bedoya MA, Jaimes C, Khrichenko K et al (2014) Dynamic gadolinium-enhanced MRI of the proximal femur: preliminary experience in healthy children. AJR Am J Roentgenol 203:W440–W446

    Article  PubMed  Google Scholar 

  38. Malattia C, Damasio MB, Basso C et al (2010) Dynamic contrast-enhanced magnetic resonance imaging in the assessment of disease activity in patients with juvenile idiopathic arthritis. Rheumatology 49:178–185

    Article  PubMed  Google Scholar 

  39. Hyun H, Owens EA, Wada H et al (2015) Cartilage-specific near-infrared fluorophores for biomedical imaging. Angew Chem Int Ed Eng 54:8648–8652

    Article  CAS  Google Scholar 

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Correspondence to Susan Cheng Shelmerdine.

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Shelmerdine, S.C., Di Paolo, P.L., Tanturri de Horatio, L. et al. Imaging of the hip in juvenile idiopathic arthritis. Pediatr Radiol 48, 811–817 (2018). https://doi.org/10.1007/s00247-017-4022-7

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  • DOI: https://doi.org/10.1007/s00247-017-4022-7

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