Abstract
Tumors of the foot are rare in children. In this review the authors illustrate radiographic, sonographic and MR imaging findings of foot soft-tissue tumors in children based on all cases presenting at a tertiary pediatric hospital during the 15-year period of 1999–2014. Among these cases there were 155 tumors of the foot — 72 of the bones and 83 of the soft tissues. Vascular malformations, fibromatosis and sarcomas were respectively the most frequent benign, intermediate and malignant soft-tissue tumors. Some tumors showed specific imaging findings. In imaging investigations, ultrasound can be used as the first imaging modality for diagnostic workup of most lesions because it is noninvasive, low-cost and readily available, and can confirm the presence of the mass and evaluate cystic components, especially in young children who would otherwise require sedation for MR imaging. MR imaging is the reference standard technique because of its high tissue contrast, which allows for detection and characterization of soft-tissue and bone abnormalities. MR imaging is useful as the first imaging modality in select cases, including those with high suspicion of malignancy, very large lesions or pre-treatment lesions. Recognition of some typical imaging findings in pediatric soft-tissue foot tumors is helpful to establish diagnosis and facilitate patient management.
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References
Kransdorf MJ, Murphey MD, Bralow L (1997) Imaging of soft tissue tumors, 1st edn. WB Saunders, Philadelphia
Navarro OM, Laffan EE, Ngan BY (2009) Pediatric soft-tissue tumors and pseudotumors: MR imaging with pathologic correlation. Part 1. Imaging approach, pseudotumors, vascular lesions, and adipocytic tumors. Radiographics 29:887–906
Singer AD, Datir A, Tresley J et al (2016) Benign and malignant tumors of the foot and ankle. Skelet Radiol 45:287–305
Gartner L, Pearce CJ, Saifuddin A (2009) The role of the plain radiograph in the characterisation of soft tissue tumours. Skelet Radiol 38:549–558
Fornage BD, Rifkin MD (1988) Ultrasound examination of the hand and foot. Radiol Clin N Am 26:109–129
Paltiel HJ, Burrows PE, Kozakewich HP et al (2000) Soft-tissue vascular anomalies: utility of US for diagnosis. Radiology 214:747–754
Totty WG, Murphy WA, Lee JK (1986) Soft-tissue tumors: MR imaging. Radiology 160:135–141
Gielen JL, De Schepper AM, Vanhoenacker F et al (2004) Accuracy of MRI in characterization of soft tissue tumors and tumor-like lesions. A prospective study in 548 patients. Eur Radiol 14:2320–2330
Iyer RS, Thapa MM (2013) MR imaging of the paediatric foot and ankle. Pediatr Radiol 43:S107–S119
Kim JS, Chandler A, Borzykowski R et al (2012) Maximizing time-resolved MRA for differentiation of hemangiomas, vascular malformations and vascularized tumors. Pediatr Radiol 42:775–784
Guerini H, Omoumi P, Guichoux F et al (2015) Fat suppression with Dixon techniques in musculoskeletal magnetic resonance imaging: a pictorial review. Semin Musculoskelet Radiol 19:335–347
Zou Y, Wang QD, Zong M et al (2016) Apparent diffusion coefficient measurements with diffusion-weighted imaging for differential diagnosis of soft-tissue tumor. J Cancer Res Ther 12:864–870
Brisse H, Orbach D, Klijanienko J et al (2006) Imaging and diagnostic strategy of soft tissue tumors in children. Eur Radiol 16:1147–1164
Fisher C (1996) Soft tissue sarcomas: diagnosis, classification and prognostic factors. Br J Plast Surg 49:27–33
Fletcher CD, Hogendoorn P, Mertens F et al (2013) WHO classification of tumours of soft tissue and bone, 4th edn. IARC Press, Lyon
Wassef M, Blei F, Adams D et al (2015) Vascular anomalies classification: recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics 136:e203–e214
Sheybani EF, Eutsler EP, Navarro OM (2016) Fat-containing soft-tissue masses in children. Pediatr Radiol 46:1760–1773
Boybeyi O, Alanay Y, Kayikçioğlu A et al (2010) Hemihyperplasia-multiple lipomatosis syndrome: an underdiagnosed entity in children with asymmetric overgrowth. J Pediatr Surg 45:E19–E23
Lee JC, Thomas JM, Phillips S et al (2006) Aggressive fibromatosis: MRI features with pathologic correlation. AJR Am J Roentgenol 186:247–254
Sargar KM, Sheybani EF, Shenoy A et al (2016) Pediatric fibroblastic and myofibroblastic tumors: a pictorial review. Radiographics 36:1195–1214
Murphey MD, Ruble CM, Tyszko SM et al (2009) Musculoskeletal fibromatoses: radiologic-pathologic correlation. Radiographics 29:2143–2173
Vogel D, Righi A, Kreshak J et al (2014) Lipofibromatosis: magnetic resonance imaging features and pathological correlation in three cases. Skelet Radiol 43:633–639
Kransdorf MJ, Meis JM, Jelinek JS (1991) Myositis ossificans: MR appearance with radiologic pathologic correlation. AJR Am J Roentgenol 157:1243–1248
Lacout A, Jarraya M, Marcy PY et al (2012) Myositis ossificans imaging: keys to successful diagnosis. Indian J Radiol Imaging 22:35–39
Gindele A, Schwamborn D, Tsironis K et al (2000) Myositis ossificans traumatica in young children: report of three cases and review of the literature. Pediatr Radiol 30:451–459
Laffan EE, Ngan BY, Navarro OM (2009) Pediatric soft-tissue tumors and pseudotumors: MR imaging features with pathologic correlation: part 2. Tumors of fibroblastic/myofibroblastic, so-called fibrohistiocytic, muscular, lymphomatous, neurogenic, hair matrix, and uncertain origin. Radiographics 29:e36
Gibbons CL, Khwaja HA, Cole AS et al (2002) Giant-cell tumour of the tendon sheath in the foot and ankle. J Bone Joint Surg Br 84:1000–1003
Gonzalez S, Duarte I (1982) Benign fibrous histiocytoma of the skin. A morphologic study of 290 cases. Pathol Res Pract 174:379–391
Mankin HJ, Casas-Ganem J, Kim JI et al (2004) Leiomyosarcoma of somatic soft tissues. Clin Orthop Relat Res 421:225–231
Gordon RW, Tirumani SH, Kurra V et al (2014) MRI, MDCT features, and clinical outcome of extremity leiomyosarcomas: experience in 47 patients. Skelet Radiol 43:615–622
Navarro OM (2016) Magnetic resonance imaging of pediatric soft-tissue vascular anomalies. Pediatr Radiol 46:891–901
Cohen MM Jr (2000) Klippel-Trenaunay syndrome. Am J Med Genet 93:171–175
White CL, Olivieri B, Restrepo R et al (2016) Low-flow vascular malformation pitfalls: from clinical examination to practical imaging evaluation – part 1, lymphatic malformation mimickers. AJR Am J Roentgenol 206:940–951
Rogers M, Lam A, Fischer G (2002) Sonographic findings in a series of rapidly involuting congenital hemangiomas (RICH). Pediatr Dermatol 19:5–11
Subash A, Senthil GK, Ramamoorthy R et al (2015) Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon in a neonate of life- and limb-threatening nature: a case report. J Indian Assoc Pediatr Surg 20:194–196
Bahnassy M, Abdul-Khalik H (2009) Soft tissue chondroma: a case report and literature review. Oman Med J 24:296–299
Shapeero LG, Vanel D, Couanet D et al (1993) Extraskeletal mesenchymal chondrosarcoma. Radiology 186:819–826
Lim R, Jaramillo D, Poussaint TY et al (2005) Superficial neurofibroma: a lesion with unique MRI characteristics in patients with neurofibromatosis type 1. AJR Am J Roentgenol 184:962–968
Yikilmaz A, Ngan BY, Navarro OM (2015) Imaging of childhood angiomatoid fibrous histiocytoma with pathological correlation. Pediatr Radiol 45:1796–1802
Jo VY, Antonescu CR, Zhang L et al (2013) Cutaneous syncytial myoepithelioma: clinicopathologic characterization in a series of 38 cases. Am J Surg Pathol 37:710–718
McCarville MB, Spunt SL, Skapek SX et al (2002) Synovial sarcoma in pediatric patients. AJR Am J Roentgenol 179:797–801
Cypel TK, Meilik B, Zuker RM (2007) Extraskeletal Ewing’s sarcoma in a great toe of a young boy. Can J Plast Surg 15:165–168
Bakst RL, Tallman MS, Douer D et al (2011) How I treat extramedullary acute myeloid leukemia. Blood 118:3785–3793
Pui MH, Fletcher BD, Langston JW (1994) Granulocytic sarcoma in childhood leukemia: imaging features. Radiology 190:698–702
Fritz J, Vogel W, Bares R et al (2007) Radiologic spectrum of extramedullary relapse of acute myelogenous leukemia in adults. AJR Am J Roentgenol 189:209–218
Alyas F, Lee J, Ahmed M et al (2007) Prevalence and diagnostic significance of fluid–fluid levels in soft-tissue neoplasms. Clin Radiol 62:769–774
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Caro-Domínguez, P., Navarro, O.M. Imaging appearances of soft-tissue tumors of the pediatric foot: review of a 15-year experience at a tertiary pediatric hospital. Pediatr Radiol 47, 1555–1571 (2017). https://doi.org/10.1007/s00247-017-3940-8
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DOI: https://doi.org/10.1007/s00247-017-3940-8