Factors influencing the diagnostic yield and accuracy of image-guided percutaneous needle biopsy of pediatric tumors: single-center audit of a 26-year experience
- 241 Downloads
Image-guided percutaneous core needle biopsy is a common procedure for diagnosis of both solid tumors and hematological malignancies in children. Despite recent improvements, a certain rate of non-diagnostic biopsies persists.
To assess the factors influencing the diagnostic yield and accuracy of percutaneous core needle biopsies of pediatric tumors.
Materials and methods
We conducted a single-center retrospective study of a 26-year experience with image-guided biopsies in children and young adults. Using uni- and multivariate analysis, we evaluated the association of diagnostic yield and accuracy with technical factors (image-guided procedure, pathological technique) and clinical factors (complication rate, histological type and anatomical location).
We retrieved data relating to 396 biopsies were performed in 363 children and young adults (mean age: 7.4 years). Overall, percutaneous core needle biopsy showed a diagnostic yield of 89.4% (95% confidence interval [CI] 85.9–92.2) and an accuracy of 90.9% (CI 87.6–93.6) with a complication rate of 2.5% (CI 1.2–4.6).The diagnostic yield increased with the use of advanced tissue assessment techniques (95.7% with immunohistochemistry versus 82.3% without immunohistochemistry; P < 0.0001) and an increased number of passes (mean: 3.96 for diagnostic biopsies versus 3.62 for non-diagnostic biopsies; P = 0.044).
The use of advanced pathological techniques and an increased number of passes are the two main factors influencing the diagnostic success of biopsies in pediatric tumors.
KeywordsChild Core needle biopsy Diagnosis Image guidance Neoplasm Percutaneous biopsy
We would like to express our grateful thanks to Mr. James Winter for helping in the preparation of the manuscript.
Compliance with Ethical Standards
Conflicts of interest
- 15.Fleiss JL (1981) Statistical methods for rates and proportions. Wiley, New YorkGoogle Scholar