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Pediatric Radiology

, Volume 46, Issue 3, pp 372–382 | Cite as

Factors influencing the diagnostic yield and accuracy of image-guided percutaneous needle biopsy of pediatric tumors: single-center audit of a 26-year experience

  • Eléonore BlondiauxEmail author
  • Méryle Laurent
  • Etienne Audureau
  • Sabah Boudjemaa
  • Chiara Sileo
  • Marion Lenoir
  • Linda Dainese
  • Catherine Garel
  • Aurore Coulomb
  • Hubert Ducou le Pointe
Original Article

Abstract

Background

Image-guided percutaneous core needle biopsy is a common procedure for diagnosis of both solid tumors and hematological malignancies in children. Despite recent improvements, a certain rate of non-diagnostic biopsies persists.

Objective

To assess the factors influencing the diagnostic yield and accuracy of percutaneous core needle biopsies of pediatric tumors.

Materials and methods

We conducted a single-center retrospective study of a 26-year experience with image-guided biopsies in children and young adults. Using uni- and multivariate analysis, we evaluated the association of diagnostic yield and accuracy with technical factors (image-guided procedure, pathological technique) and clinical factors (complication rate, histological type and anatomical location).

Results

We retrieved data relating to 396 biopsies were performed in 363 children and young adults (mean age: 7.4 years). Overall, percutaneous core needle biopsy showed a diagnostic yield of 89.4% (95% confidence interval [CI] 85.9–92.2) and an accuracy of 90.9% (CI 87.6–93.6) with a complication rate of 2.5% (CI 1.2–4.6).The diagnostic yield increased with the use of advanced tissue assessment techniques (95.7% with immunohistochemistry versus 82.3% without immunohistochemistry; P < 0.0001) and an increased number of passes (mean: 3.96 for diagnostic biopsies versus 3.62 for non-diagnostic biopsies; P = 0.044).

Conclusion

The use of advanced pathological techniques and an increased number of passes are the two main factors influencing the diagnostic success of biopsies in pediatric tumors.

Keywords

Child Core needle biopsy Diagnosis Image guidance Neoplasm Percutaneous biopsy 

Notes

Acknowledgments

We would like to express our grateful thanks to Mr. James Winter for helping in the preparation of the manuscript.

Compliance with Ethical Standards

Conflicts of interest

None

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Eléonore Blondiaux
    • 1
    Email author
  • Méryle Laurent
    • 1
  • Etienne Audureau
    • 2
  • Sabah Boudjemaa
    • 3
  • Chiara Sileo
    • 1
  • Marion Lenoir
    • 1
  • Linda Dainese
    • 3
  • Catherine Garel
    • 1
  • Aurore Coulomb
    • 3
  • Hubert Ducou le Pointe
    • 1
  1. 1.Department of Radiology, Hôpital Armand-Trousseau–Hôpitaux Universitaires de l’Est Parisien (Assistance Publique - Hôpitaux de Paris)Université Pierre et Marie CurieParisFrance
  2. 2.Public Health Department, Hôpital Henri Mondor, Assistance Publique Hôpitaux de Paris, CEpiA EA7376Université Paris Est Créteil (UPEC)CréteilFrance
  3. 3.Department of Pathology, Hôpital Trousseau–Hôpitaux Universitaires de l’Est Parisien (Assistance Publique - Hôpitaux de Paris)Université Pierre et Marie CurieParisFrance

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