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All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia

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Abstract

All-trans retinoic acid (ATRA), a component of standard therapy for acute promyelocytic leukemia (APL), is associated with potentially serious but treatable adverse effects involving numerous organ systems, including rare skeletal muscle involvement. Only a handful of cases of ATRA-induced myositis in children have been reported, and none in the radiology literature. We present such a case in a 15-year-old boy with APL, where recognition of imaging findings played a crucial role in making the diagnosis and facilitated prompt, effective treatment.

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Authors and Affiliations

  1. Children’s National Medical Center, Division of Oncology, Center for Cancer and Blood Disorders, 111 Michigan Avenue, NW, Washington, DC, 20010, USA

    Lydia H. Pecker & Anne Angiolillo

  2. Division of Diagnostic Imaging and Radiology, Children’s National Medical Center, Washington, DC, USA

    Jason Tsai

Authors
  1. Lydia H. Pecker
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  2. Jason Tsai
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  3. Anne Angiolillo
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Correspondence to Lydia H. Pecker.

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Pecker, L.H., Tsai, J. & Angiolillo, A. All-trans retinoic acid-induced inflammatory myositis in a patient with acute promyelocytic leukemia. Pediatr Radiol 44, 1039–1041 (2014). https://doi.org/10.1007/s00247-014-2951-y

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  • DOI: https://doi.org/10.1007/s00247-014-2951-y

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