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Body growth and brain development in premature babies: an MRI study

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Abstract

Background

Prematurity and intrauterine growth restriction are associated with neurodevelopmental disabilities.

Objective

To assess the relationship between growth status and regional brain volume (rBV) and white matter microstructure in premature babies at around term-equivalent age.

Materials and methods

Premature infants (n= 27) of gestational age (GA): 29.8 ± 2.1 weeks, with normal brain MRI scans were studied at corrected age: 41.2 ± 1.4 weeks. The infants were divided into three groups: 1) appropriate for GA at birth and at the time of MRI (AGA), 2) small for GA at birth with catch-up growth at the time of MRI (SGAa) and 3) small for GA at birth with failure of catch-up growth at the time of MRI (SGAb). The T1-weighted images were segmented into 90 rBVs using the SPM8/IBASPM and differences among groups were assessed. Fractional anisotropy (FA) was measured bilaterally in 15 fiber tracts and its relationship to GA and somatometric measurements was explored.

Results

Lower rBV was observed in SGAb in superior and anterior brain areas. A positive correlation was demonstrated between FA and head circumference and body weight. Body weight was the only significant predictor for FA (P< 0.05).

Conclusion

In premature babies, catch-up growth is associated with regional brain volume catch-up at around term-equivalent age, starting from the brain areas maturing first. Body weight seems to be a strong predictor associated with WM microstructure in brain areas related to attention, language, cognition, memory and executing functioning.

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Authors and Affiliations

  1. Department of Radiology, Medical School, University of Ioannina, 45110, Ioannina, Greece

    Loukia C. Tzarouchi, Anastasia Zikou, Paraskevi Kosta & Maria I. Argyropoulou

  2. Intensive Care Unit, Child Health Department, Medical School, University of Ioannina, Ioannina, Greece

    Aikaterini Drougia & Styliani Andronikou

  3. Department of Medical Physics, Medical School, University of Ioannina, Ioannina, Greece

    Loukas G. Astrakas

Authors
  1. Loukia C. Tzarouchi
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  2. Aikaterini Drougia
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  3. Anastasia Zikou
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  6. Styliani Andronikou
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  7. Maria I. Argyropoulou
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Correspondence to Maria I. Argyropoulou.

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Tzarouchi, L.C., Drougia, A., Zikou, A. et al. Body growth and brain development in premature babies: an MRI study. Pediatr Radiol 44, 297–304 (2014). https://doi.org/10.1007/s00247-013-2822-y

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  • DOI: https://doi.org/10.1007/s00247-013-2822-y

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