Prospective motion correction improves diagnostic utility of pediatric MRI scans
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A new technique for prospectively correcting head motion (called PROMO) during acquisition of high-resolution MRI scans has been developed to reduce motion artifacts. To evaluate the efficacy of PROMO, four T1-weighted image volumes (two with PROMO enabled, two uncorrected) were acquired for each of nine children. A radiologist, blind to whether PROMO was used, rated image quality and artifacts on all sagittal slices of every volume. These ratings were significantly better in scans collected with PROMO relative to those collected without PROMO (Mann-Whitney U test, P < 0.0001). The use of PROMO, especially in motion-prone patients, should improve the accuracy of measurements made for clinical care and research, and potentially reduce the need for sedation in children.
KeywordsMotion correction Head motion MRI Children
The authors would like to thank the children and parents who volunteered to participate in this study, which was supported by grants from the National Institutes of Health Specialized Neuroscience Research Programs (U54 NS056883), the National Institute on Drug Abuse (RC2 DA029475), the National Institute of Neurological Disorders and Stroke (P50 NS022343), support from General Electric, and by a fellowship from the UCSD Institute for Neural Computation.
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