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Accuracy of CT-guided percutaneous core needle biopsy for assessment of pediatric musculoskeletal lesions

Pediatric Radiology volume 41, pages 848–857 (2011)Cite this article

Abstract

Background

CT-guided percutaneous core needle biopsy has been shown in adults to be an effective diagnostic tool for a large number of musculoskeletal malignancies.

Objective

To characterize our experience with CT-guided percutaneous core needle biopsy of pediatric bone lesions and determine its utility in diagnosing pediatric osseous lesions, in a population where such lesions are commonly benign.

Materials and methods

From 2000 to 2009, 61 children underwent 63 CT-guided percutaneous biopsies. Radiological, pathological and clinical records were reviewed.

Results

Fourteen biopsies (22%) were performed on malignant lesions, while 49 biopsies (78%) were performed on benign lesions. Forty-nine of the 63 biopsies (78%) were adequate; these children underwent no further tissue sampling. Fourteen of the 63 biopsies (22%) were inadequate or non-conclusive. Of these patients, 12 underwent open biopsy. Retrospective analysis of percutaneous biopsies in these patients demonstrates that 9/12 provided clinically relevant information, and 4/12 patients received final diagnoses that confirmed initial core biopsy findings. No malignancies were diagnosed as benign on percutaneous biopsy. Overall, percutaneous core needle biopsy provided accurate diagnostic information in 84% (53/63) of biopsies.

Conclusion

Our results demonstrate that CT-guided percutaneous biopsy is safe and beneficial in children. This study supports the use of CT-guided percutaneous core needle biopsy for primary diagnosis of pediatric bone lesions.

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Author notes

  1. Anastasia L. Hryhorczuk

    Present address: Department of Radiology, Boston Children’s Hospital, Harvard University School of Medicine, 300 Longwood Ave., Boston, MA, 02115, USA

Affiliations

  1. Department of Radiology, C. S. Mott Children’s Hospital, University of Michigan, Ann Arbor, MI, USA

    Anastasia L. Hryhorczuk & Peter J. Strouse

  2. Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI, USA

    J. Sybil Biermann

Authors
  1. Anastasia L. Hryhorczuk
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  2. Peter J. Strouse
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  3. J. Sybil Biermann
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Corresponding author

Correspondence to Anastasia L. Hryhorczuk.

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Hryhorczuk, A.L., Strouse, P.J. & Biermann, J.S. Accuracy of CT-guided percutaneous core needle biopsy for assessment of pediatric musculoskeletal lesions. Pediatr Radiol 41, 848–857 (2011). https://doi.org/10.1007/s00247-010-1970-6

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  • DOI: https://doi.org/10.1007/s00247-010-1970-6

Keywords

  • CT
  • Musculoskeletal
  • Biopsy
  • Interventional
  • Children