Advertisement

Pediatric Radiology

, Volume 40, Issue 8, pp 1436–1439 | Cite as

Perinatal clinical and imaging features of CLOVES syndrome

  • Israel Fernandez-Pineda
  • Manuel Fajardo
  • Gulraiz Chaudry
  • Ahmad I. Alomari
Case Report

Abstract

We report a neonate with antenatal imaging features suggestive of CLOVES syndrome. Postnatal clinical and imaging findings confirmed the diagnosis, with the constellation of truncal overgrowth, cutaneous capillary malformation, lymphatic and musculoskeletal anomalies. The clinical, radiological and histopathological findings noted in this particular phenotype help differentiate it from other overgrowth syndromes with complex vascular anomalies.

Keywords

CLOVES syndrome Antenatal diagnosis Vascular anomalies Overgrowth syndromes Child 

References

  1. 1.
    Sapp JC, Turner JT, van de Kamp JM et al (2007) Newly delineated syndrome of congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (CLOVE syndrome) in seven patients. Am J Med Genet A 143A:2944–2958CrossRefPubMedGoogle Scholar
  2. 2.
    Alomari AI (2009) Characterization of a distinct syndrome that associates complex truncal overgrowth, vascular, and acral anomalies: a descriptive study of 18 cases of CLOVES syndrome. Clin Dysmorphol 18:1–7CrossRefPubMedGoogle Scholar
  3. 3.
    Alomari AI (2009) CLOVE(S) syndrome: expanding the acronym. Am J Med Genet 149A:294CrossRefPubMedGoogle Scholar
  4. 4.
    Happle R (1987) Lethal genes surviving by mosaicism: a possible explanation for sporadic birth defects involving the skin. J Am Acad Dermatol 16:899–906CrossRefPubMedGoogle Scholar
  5. 5.
    Sigaudy S, Fredouille C, Gambarelli D et al (1998) Prenatal ultrasonographic findings in Proteus syndrome. Prenat Diagn 10:1091–1094CrossRefGoogle Scholar
  6. 6.
    De Smet L, Fryns JP (1994) Proteus syndrome and unilateral congenital windblown hand deformity. Am J Med Genet 49:136CrossRefPubMedGoogle Scholar
  7. 7.
    Goldstein I, Jakobi P, Shoshany G et al (1994) Late-onset isolated cystic hygroma: the obstetrical significance, management, and outcome. Prenat Diagn 14:757–761CrossRefPubMedGoogle Scholar
  8. 8.
    Fryns JP (1995) Late-onset isolated cystic hygroma. A first clinical sign of Proteus syndrome. Prenat Diagn 15:96–97CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Israel Fernandez-Pineda
    • 1
  • Manuel Fajardo
    • 2
  • Gulraiz Chaudry
    • 3
  • Ahmad I. Alomari
    • 3
  1. 1.Department of Pediatric SurgeryVirgen del Rocio Children’s HospitalSevilleSpain
  2. 2.Department of Pediatric RadiologyVirgen del Rocio Children’s HospitalSevilleSpain
  3. 3.Division of Vascular and Interventional RadiologyChildren’s Hospital Boston and Harvard Medical SchoolBostonUSA

Personalised recommendations