Skip to main content

Acute necrotizing encephalopathy secondary to diphtheria, tetanus toxoid and whole-cell pertussis vaccination: diffusion-weighted imaging and proton MR spectroscopy findings

Abstract

We present a previously healthy 6-month-old boy who was admitted to our hospital with lethargy, hypotonia and focal clonic seizures 6 days following diptheria, tetanus toxoid and whole-cell pertussis vaccination. A diagnosis of acute necrotising encephalopathy was made with the aid of MRI, including diffusion-weighted imaging and proton MR spectroscopy.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2
Fig. 3

References

  1. Kim JH, Kim IO, Lim MK et al (2004) Acute necrotizing encephalopathy in Korean infants and children: imaging findings and diverse clinical outcome. Korean J Radiol 5:171–177

    Article  PubMed  Google Scholar 

  2. Mizuguchi M (1997) Acute necrotizing encephalopathy of childhood: a novel form of acute encephalopathy prevalent in Japan and Taiwan. Brain Dev 19:81–92

    Article  CAS  PubMed  Google Scholar 

  3. Goo HW, Choi CG, Yoon CH et al (2003) Acute necrotizing encephalopathy: diffusion MR imaging and localized proton MR spectroscopic findings in two infants. Korean J Radiol 4:61–65

    Article  PubMed  Google Scholar 

  4. Lavigne MV, Castro M, Mateo N et al (2000) Whole-cell Bordetella pertussis vaccine component modulates the mouse immune response to an unrelated soluble antigen. Microbes Infect 4:815–820

    Article  Google Scholar 

  5. Fantuzzi G, Sironi M, Delgado R et al (1994) Depression of liver metabolism and induction of cytokine release by diphtheria and tetanus toxoids and pertussis vaccines: role of Bordetella pertussis cells in toxicity. Infect Immun 96:29–32

    Google Scholar 

  6. Harada M, Hisaoka S, Mori K et al (2000) Differences in water diffusion and lactate production in two different types of postinfectious encephalopathy. J Magn Reson Imaging 11:559–563

    Article  CAS  PubMed  Google Scholar 

  7. Albayram S, Bilgi Z, Selcuk H et al (2004) Diffusion-weighted MR imaging findings of acute necrotizing encephalopathy. AJNR 25:792–797

    PubMed  Google Scholar 

  8. Mizuguchi M, Hayashi M, Nakano I et al (2002) Concentric structure of thalamic lesions in acute necrotizing encephalopathy. Neuroradiology 44:489–493

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hale Aydin.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Aydin, H., Ozgul, E. & Agildere, A.M. Acute necrotizing encephalopathy secondary to diphtheria, tetanus toxoid and whole-cell pertussis vaccination: diffusion-weighted imaging and proton MR spectroscopy findings. Pediatr Radiol 40, 1281–1284 (2010). https://doi.org/10.1007/s00247-009-1498-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-009-1498-9

Keywords

  • Encephalopathy
  • Vaccination
  • MRI
  • Diffusion
  • Spectroscopy
  • Child